Prinzide (Lisinopril/Hctz)


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$65.00 ($0.77 per tablet)

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Prinzide is utilized in the treatment of high blood pressure, aiming to reduce the risk of strokes, heart attacks, and kidney problems associated with elevated blood pressure levels. 

Prinzide contains two active ingredients: lisinopril, an ACE inhibitor that relaxes blood vessels to facilitate improved blood flow, and hydrochlorothiazide, a diuretic that promotes increased urine production to help the body eliminate excess salt and water.

This product may be prescribed when a single medication is insufficient in controlling high blood pressure. 


  • Take Prinzide exactly as prescribed by your healthcare provider, with or without food.
  • Take it once daily in the morning, ideally.
  • If nighttime urination troubles you, take it at least 4 hours before bedtime.
  • If taking cholesterol-lowering resins (cholestyramine or colestipol), separate Prinzide by 4 hours before or 4-6 hours after.
  • Take Prinzide consistently, preferably at the same time each day.
  • Continue taking Prinzide even if you feel well, as high blood pressure often has no symptoms.
  • Inform your healthcare provider if your blood pressure improves or worsens.


  • Don't take more or less medication than prescribed.
  • Don't stop taking Prinzide without consulting your healthcare provider.
  • Don't take Prinzide right before bedtime if it increases urination at night.

Common side effects:

  • Headache
  • Nausea
  • Vomiting
  • Dizziness
  • Weakness
  • Cough
  • Changes in taste
  • Muscle pain
  • Dry mouth
  • Increased urination
  • Numbness, tingling, or itching
  • Sore throat
  • Runny or stuffy nose

Serious side effects that may require immediate medical attention include:

  • Angioedema: swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness
  • Eye problems such as myopia and angle-closure glaucoma
  • Serious allergic reactions, including rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing
  • Injury or death to the fetus if taken during pregnancy
  • Worsening chest pain
  • Fainting
  • Pressure/fullness in the head
  • Confusion
  • Anxiety
  • Vision problems
  • Marked elevation of supine arterial blood pressure (supine hypertension)
  • Symptoms of liver damage, including nausea/vomiting that doesn't stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine
  • Serious allergic reactions, including anaphylaxis, which can be life-threatening
  • Serious problems such as heart failure, blood vessel disease, stroke, or kidney disease if high blood pressure is not treated

This is not an exhaustive list, and other side effects may occur. If you experience any unusual or severe side effects while taking Prinzide,  contact your healthcare provider for medical advice.

Tell your healthcare provider if you are allergic to lisinopril, hydrochlorothiazide, other ACE inhibitors, or any ingredients in Prinzide.

Discuss medical conditions with your healthcare provider. History of allergic reactions, including swelling of the face, lips, tongue, or throat (angioedema)

  • Blood filtering procedures (such as LDL apheresis, and dialysis)
  • Desensitization treatment for bee/wasp sting allergy
  • Gout, lupus, kidney disease, liver disease, or skin cancer

Prinzide may cause dizziness. Avoid driving, operating machinery, or activities requiring alertness until you feel safe. Limit alcohol and marijuana use.

Severe sweating, diarrhea, or vomiting can lead to dehydration. Tell your healthcare provider if you experience these symptoms. Drink plenty of fluids unless your healthcare provider advises otherwise.

Prinzide may affect your blood sugar levels if you have diabetes. Monitor your blood sugar regularly and tell your healthcare provider about the results. Your diabetes medication, exercise program, or diet may need adjustment.

Prinzide may increase your sun sensitivity and risk of skin cancer. Limit sun exposure, avoid tanning booths and sunlamps, use sunscreen, and wear protective clothing outdoors. Tell your healthcare provider about any sunburns, skin blisters/redness, or new/changed moles/skin lesions.

Prinzide may affect your potassium levels. Consult your healthcare provider before using potassium supplements or salt substitutes containing potassium.

Before having surgery, tell your healthcare provider about all medications you take, including Prinzide.

Older adults may be more sensitive to side effects, especially dizziness and changes in urine amount (kidney problems).

Prinzide can harm an unborn baby. Do not become pregnant while using it. Tell your healthcare provider immediately if you become pregnant. It is unknown if lisinopril passes into breast milk. Hydrochlorothiazide does but is unlikely to harm a nursing infant. Consult your healthcare provider before breastfeeding.

Prinzide can cause serious (possibly fatal) harm to an unborn baby. It's important to prevent pregnancy while taking this medication. Discuss reliable birth control methods with your healthcare provider. If you are planning pregnancy, become pregnant, or think you may be pregnant, tell your healthcare provider right away.

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Strength(s): 10/12.5mg
Quantities Available: 84


Important Information
The information above for Prinzide (Lisinopril/Hctz) was provided to by third parties. In no way should this information substitute for the advice of a physician. Consult a doctor or qualified health care professional if you have any medical concerns. widget logo
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