Actikerall (Fluorouracil/Salicylic Acid)


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Fluorouracil/Salicylic Acid

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Actikerall is a medication used to treat a skin condition called actinic keratosis. Actinic keratoses are small crusty, scaly, or crumbly patches of skin that commonly occur in people who have had a lot of sun exposure. These skin changes may be red or light brown and can be dry or rough to the touch. Actinic keratoses are often easier to feel than see

Actikerall contains two active ingredients: fluorouracil and salicylic acid. Fluorouracil is a cytotoxic antimetabolite, while salicylic acid is a keratolytic. 

Salicylic acid works by breaking down keratin, a protein that forms part of the skin structure. This results in the shedding of skin cells and softening of the skin in the treated area, which makes it easier for the fluorouracil to penetrate into the skin lesion. 

Fluorouracil interferes with the growth of abnormal cells. It causes the death of abnormal cells present in actinic keratosis lesions, leading to the shedding of the lesion and the formation of new, healthy skin cells.


  • Apply Actikerall solution exactly as prescribed by your healthcare provider, typically once daily to the affected skin areas.
  • Clean and dry the affected skin area thoroughly before applying the solution.
  • Use a thin layer of the solution, applying it only to the affected areas.
  • Apply the solution using the provided brush applicator. Wipe excess solution off the brush on the neck of the bottle before applying.
  • Allow the solution to dry completely before covering the treated area.
  • Wash your hands thoroughly with soap and water after applying Actikerall solution, unless treating your hands.
  • Avoid getting Actikerall solution in your eyes, nose, or mouth. If contact occurs, rinse thoroughly with water.


  • Don't apply Actikerall solution more often or to a larger area than prescribed.
  • Don't use bandages or dressings that don't allow the skin to breathe on treated areas unless directed by your healthcare provider. Avoid applying heat to the treated areas.
  • Don't use the Actikerall solution on infected, broken, or irritated skin.
  • Don't use the Actikerall solution past its expiration date.
  • Don't use the Actikerall solution for longer than 12 weeks without consulting your healthcare provider.
  • Don't use/ Minimize sun exposure on treated areas and use sunscreen as directed by your healthcare provider.

Common Side Effects:

  • Staining: This solution may cause permanent staining to clothing, fabric, or acrylics, such as bathtubs. Avoid contact with these until the solution has dried.
  • Nausea and vomiting
  • Constipation
  • Headache
  • Dizziness
  • Restlessness
  • Anxiety
  • Insomnia
  • Fatigue
  • Weight gain
  • Increased or decreased appetite
  • Dry mouth
  • Fruity breath odor
  • Diarrhea
  • Skin reactions if applied more than once a day
  • Dry, rough, or scaly skin patches
  • Red or light brown patches of skin
  • Dry or rough to touch skin
  • Skin changes due to sun exposure

Serious Side Effects:

  • Serious skin reactions if applied more than once a day
  • Increased risk of skin reactions in areas with thin skin
  • Increased risk of skin reactions if the effect of Actikerall is too strong
  • Increased risk of skin reactions if the enzyme responsible for breaking down the active component of the medicine is not functioning properly
  • Interactions with antiepileptic drugs (phenytoin)
  • Increased risk of skin reactions with certain other medicines
  • Methemoglobinemia (a serious blood problem where red blood cells cannot bring enough oxygen to the body)

This is not an exhaustive list, and other side effects may occur. If you experience any unusual or severe side effects while taking Actikerall,  contact your healthcare provider for medical advice.

Do not apply to eyes, or mucous membranes (inside nose, mouth, or genitals). Actikerall solution can cause irritation in these sensitive areas.

Keep away from fire or open flames, including lit cigarettes or hair dryers, while applying and until the solution dries completely.

Actikerall solution may cause temporary redness, stinging, or burning at the application site. Inform your healthcare provider if these effects are severe or persistent.

Actikerall solution may increase sun sensitivity. Minimize sun exposure, use sunscreen with SPF 15 or higher, and wear protective clothing while using this medication and for a week after stopping treatment.

Do not use Actikerall solution past its expiry date.

Do not use Actikerall solution if you notice crystals forming in the bottle.

Avoid contact with fabrics or acrylic surfaces (bathtubs) as Actikerall solution may stain them permanently.

Inform your healthcare provider about all medications you are using, including prescription drugs, over-the-counter medications, vitamins, and herbal products.

Pregnancy and Breastfeeding: Discuss the risks and benefits of using Actikerall solution with your healthcare provider if you are pregnant or breastfeeding.

Consult your healthcare provider before using the Actikerall solution if you have any skin conditions other than actinic keratosis.

Brand Name:


Generic name:

Fluorouracil/Salicylic Acid

Other Names:


Strength(s): 0.5%/10%
Quantities Available: 25


Important Information
The information above for Actikerall (Fluorouracil/Salicylic Acid) was provided to by third parties. In no way should this information substitute for the advice of a physician. Consult a doctor or qualified health care professional if you have any medical concerns. widget logo
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