Tri-Luma Cream (Fluocinolone/Hydroquinone/Tretinoin)

Tri-Luma Cream

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Prescription RequiredPrescription Required
FormulationFormulation: Cream
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(Generic Alternative)

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This generic medication is not available at the moment.

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Tri-Luma Cream is a prescription medication indicated for the short-term treatment (up to 8 weeks) of moderate to severe melasma of the face. Melasma is a condition that causes dark, patchy areas on the skin, especially on the cheeks and forehead, and sometimes occurs with hormone changes.

This cream is a unique triple-combination topical therapy that contains three active ingredients: fluocinolone acetonide (a corticosteroid), hydroquinone (a melanin synthesis inhibitor), and tretinoin (a retinoid). This combination of ingredients makes it more effective than treatments containing only two of the ingredients.


  • Before using Tri-Luma Cream, apply a small amount to an area of unbroken skin and check for any serious side effects within 24 hours. If the test area becomes itching, red, puffy, or blistering, do not use the product and contact your healthcare provider. If there is only mild redness, then treatment with the product may begin.
  • Gently wash your face and neck with a mild soapless cleanser, rinse, and pat dry the skin.
  • Apply a thin layer of medication to the affected area, including about 1/2 inch of normal-appearing skin around the affected area as directed by your healthcare provider, usually once daily 30 minutes before bedtime. Rub the medication into the skin gently and completely.
  • Tri-Luma Cream may make the treated areas of skin more sensitive to the sun. Use a sunscreen of SPF 30 or greater and wear protective clothing on the treated areas of skin when outdoors, even on cloudy or hazy days.
  • If you experience dry skin from using this product, you may use a skin moisturizer in the morning after washing your face. Additionally, you may use a moisturizer and cosmetics during the day while using this medication.
  • Use this medication regularly to get the most benefit from it. To help you remember, use it at the same time each night.
  • Significant improvement may take up to 4 weeks to notice. However, this medication is not recommended for long-term use (such as longer than 8 weeks) without stopping the medication for short periods. If your condition lasts or gets worse after 4 weeks of treatment, inform your healthcare provider.


  • Do not bandage, cover, or wrap the treated area unless directed to do so by your healthcare provider.
  • Avoid prolonged sun exposure, tanning booths, and sunlamps.
  • Avoid getting this product in your eyes or on the inside of your nose or mouth. If contact occurs, flush with plenty of water. If severe irritation occurs, seek medical attention promptly.

Common Side Effects:

  • Dark spots on the skin
  • Tingling
  • Increased skin sensitivity
  • Rash
  • Acne
  • Skin redness caused by a condition called rosacea
  • Skin bumps
  • Blisters
  • Tiny red lines or blood vessels showing through the skin
  • Gradual blue-black darkening of the skin 

Severe Reactions:

  • Severe or continued irritation, blistering, oozing, scaling, or crusting
  • Severe burning or swelling of the skin
  • Irritation of the eyes, nose, or mouth
  • Any type of breathing problem 

Stop using Tri-Luma Cream and contact a healthcare provider if any of the listed severe reactions occur.

Discuss any concerns or potential side effects with a healthcare provider when using Tri-Luma Cream. 

You should not use Tri-Luma Cream if you are allergic to any of its ingredients, including sulfites, as this may lead to life-threatening allergic reactions.

If you are pregnant, may be pregnant, or plan to become pregnant, inform your healthcare provider, as the use of Tri-Luma Cream in pregnant women may carry the chance of causing birth defects in the baby.

Store Tri-Luma Cream in the refrigerator and avoid freezing it. Keep all medications away from children and pets. Properly discard the product when it is expired or no longer needed.

Your skin may become more sensitive to weather extremes such as cold and wind. Protect your skin with clothing and use a moisturizing cream or lotion as needed.

Tri-Luma Cream contains hydroquinone, which may cause a gradual blue-black darkening of the skin. If you notice this effect, stop using the product immediately and consult your healthcare provider

If your skin experiences excessive irritation, burning, or other severe reactions, discontinue using the cream and seek medical advice

Adhere to the prescribed usage and follow the guidance of a healthcare provider when using Tri-Luma Cream.

Brand Name:

Tri-Luma Cream

Generic name:


Other Names:

Tri Luma Cream

Strength(s): 0.01/4/0.05%
Quantities Available: 30, 60


Important Information
The information above for Tri-Luma Cream (Fluocinolone/Hydroquinone/Tretinoin) was provided to by third parties. In no way should this information substitute for the advice of a physician. Consult a doctor or qualified health care professional if you have any medical concerns. widget logo
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