Clobex Spray (Clobetasol Propionate)

Clobex Spray

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Clobetasol Propionate

(Generic Alternative)

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This generic medication is not available at the moment.

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Clobex Spray (Clobetasol) is specifically formulated for use by adults to alleviate the symptoms of moderate to severe plaque psoriasis. 

By effectively reducing the swelling, itching, and redness associated with this condition, Clobetasol provides relief. However, this medication is classified as a very potent (super-high-potency) corticosteroid, and as such, it is not recommended for use in individuals under the age of 18 due to the elevated risk of potential side effects.


  • Use Clobex Spray on the prescribed areas, avoiding the face, groin, and underarms unless your healthcare provider instructs otherwise.
  • Wash and dry your hands thoroughly before applying the spray. Clean and dry the affected skin area as well.
  • Apply a thin film of the medication to the affected area and rub it gently as directed by your healthcare provider. Typically, the application is done twice daily.
  • Wash your hands again after applying the spray, unless you're treating your hands.
  • Be very cautious when applying near the eyes. Avoid contact with eyes. If the medication gets in your eyes, rinse thoroughly with water.
  • Use Clobex Spray exactly as prescribed. Don't increase the dose, use it more frequently, or use it for longer than directed (usually 2 weeks).
  • Don't use more than one 50-gram bottle per week unless your healthcare provider specifically instructs you to do so.
  • If your condition doesn't improve or worsens after 2 weeks of using Clobex Spray, tell your healthcare provider.


  • Avoid using Clobex Spray on the face, groin, or underarms without your healthcare provider's approval.
  • Don't apply more often, in higher doses, or for longer than prescribed.
  • Don't use more than one 50-gram bottle per week unless your healthcare provider tells you to.
  • Don't bandage, wrap, or cover the treated area unless your healthcare provider instructs you to do so.

Common Side Effects:

  • Sore throat 
  • Runny nose
  • Skin thinning, which may manifest as increased susceptibility to tearing or bruising
  • Numbness or tingling at the application site
  • Upset stomach
  • Constipation
  • Blurred vision
  • Headache
  • Dizziness
  • Nausea
  • Vomiting
  • Unusual tiredness or weakness
  • Diarrhea
  • Metallic taste in the mouth
  • Skin irritation
  • Dryness, burning, itching, and redness at the application site

Serious Side Effects:

  • Signs of a serious allergic reaction: rash, hives, itching, swelling of the face, tongue, or throat, severe dizziness, and trouble breathing
  • Harmful behavior to self/others/property
  • Symptoms of skin absorption, such as weight gain in the face and shoulders, slow wound healing, skin discoloration, thinning skin, increased body hair, tiredness, mood changes, menstrual changes, and sexual changes
  • Serious skin reactions, including rash, swelling, redness, and peeling of the skin

This is not an exhaustive list, and other side effects may occur. If you experience any unusual or severe side effects while taking Clobex spray,  contact your healthcare provider for medical advice.

Disclose any allergies to clobetasol, other steroids, or any other medications to your healthcare provider.

Inform your healthcare provider about any past conditions like poor blood circulation, diabetes, other skin problems (rosacea, perioral dermatitis), or immune system problems.

Do Not Use, if there is an infection or sore in the area to be treated.

Inform your healthcare provider about using Clobex spray if you have an upcoming surgery, emergency treatment, or experience a serious illness/injury. Long-term use may affect your body's response to stress.

Regular checkups with your healthcare provider are recommended for children using Clobex spray for extended periods, as it may slow growth.

Use Clobex spray only when clearly necessary during pregnancy. Discuss risks and benefits with your healthcare provider. Consult your healthcare provider before breastfeeding as it's unknown if the medication passes into breast milk when applied to the skin.

Generic name:

Clobetasol Propionate



Strength(s): 0.05%
Quantities Available: 59
Important Information
The information above for Clobex Spray (Clobetasol Propionate) was provided to by third parties. In no way should this information substitute for the advice of a physician. Consult a doctor or qualified health care professional if you have any medical concerns. widget logo
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