Accuretic (Quinapril/HCTZ)

Do’s

• Before starting Accuretic, read the Patient Information Leaflet provided by your pharmacist. If you have any questions, ask your healthcare provider for clarification.
• Take Accuretic by mouth with or without food, as directed by your healthcare provider. 
• This medication is usually taken once daily in the morning. If taken too close to bedtime, it may lead to the need to wake up to urinate. Take this medication at least 4 hours before bedtime.
• The dosage of Accuretic is based on your medical condition and response to treatment. Take this medication regularly to receive the most benefit from it. To help you remember, take it at the same time each day. 
• Continue taking this medication even if you feel well, as most people with high blood pressure do not feel sick.
• It may take several weeks before you experience the full benefit of this product. Be patient and consistent with your medication regimen.
• This product contains magnesium, which may interfere with the absorption of some medications. Consult your healthcare provider for more information.
• If you also take certain drugs to lower your cholesterol, such as bile acid-binding resins like cholestyramine or colestipol, take Accuretic at least 4 hours before or 4 to 6 hours after these medications.
• Inform your healthcare provider if your condition does not improve or if it worsens (if your blood pressure readings remain high or increase).

Common Side Effects: 

• Tiredness (fatigue)
• Dizziness

Serious Side Effects: 

• Angioedema
• Difficulty urinating
• Allergic reactions to sulfa drugs or ACE inhibitors 

Contact your healthcare provider immediately if you experience any of these effects.

The information provided here is not exhaustive. Consult your healthcare provider for more detailed information about the potential side effects of Accuretic.

Accuretic may interfere with certain lab tests, such as parathyroid function tests, potentially leading to false results. All healthcare providers and lab personnel should be aware of your use of this medication.

If you become pregnant while taking Accuretic, consult your healthcare provider immediately to discuss the risks and benefits. 

Accuretic can pass into breast milk, discuss this with your healthcare provider if you're breastfeeding.

Accuretic can cause increases in serum creatinine and blood urea nitrogen levels, especially in patients with renal artery stenosis. Regular monitoring of these levels is recommended.

Accuretic may cause elevations in levels of uric acid, glucose, magnesium, cholesterol, triglyceride, and calcium. It can also lead to hyperglycemia, glycosuria, and hyperuricemia.

Accuretic should not be used by patients who are allergic to quinapril or hydrochlorothiazide, or any other ingredients in the tablet. It is also contraindicated for patients with a history of hereditary or idiopathic angioedema, or angioedema related to previous treatment with ACE inhibitors. It should not be administered within 36 hours of switching to or from sacubitril/valsartan, a neprilysin inhibitor.

In patients with congestive heart failure, with or without associated renal insufficiency, ACE inhibitor therapy may cause a significant drop in blood pressure. Accuretic therapy should be started under close medical supervision, and patients should be closely monitored for the first two weeks of treatment and whenever the dosage is increased.

These warnings and precautions underscore the importance of close medical supervision when using Accuretic, especially for patients with certain medical conditions or those taking other medications. If you have any specific concerns about using Accuretic, discuss them with your healthcare provider for personalized advice.