Zofran ODT
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Warning & Dosage

Zofran ODT Dosage Forms

This is available in Zofran ODT 4 mg and 8 mg orally disintegrating tablets.

Zofran ODT Mechanism of Action

The exact mechanism of this prescription drug is not fully known yet. However, this 5-HT3 receptor antagonist is known to be present peripherally on vagal nerve terminals and in the chemoreceptor trigger zone (CTZ) in the area postrema. It also blocks the release of serotonin, subsequently blocking the vomiting reflex.

How to Take Zofran ODT

Before you start with Zofran ODT treatment, it is necessary to read the information leaflet or medication guide given by a healthcare professional. It is important to understand the uses and directions of drugs before using them. Ask your doctor or pharmacist for additional details or further medical advice.

Zofran ODT is meant to be taken sublingually and is usually initiated 30 minutes to 2 hours before treatment and three times a day for one to two days after the procedure. You may administer it with or without a meal. However, most patients are advised not to eat before surgery, radiation therapy, or chemotherapy. The tablet should be placed on the tongue and allowed to dissolve. The medication may take a few seconds or minutes to absorb completely. You may have to limit the drinking of water while on this treatment. Do not chew or swallow this oral drug.

Make a dosing schedule. Do not increase or decrease your Zofran ODT dosage as it is based on your age, weight, overall health condition, and how you will respond to the product. You should also not take it more frequently. Keep taking the medication until the physician prescribes it.

Zofran ODT Warnings and Precautions

Do not take this prescription drug if you have a known allergy to ondansetron, granisetron, other anti-nausea serotonin blockers, or any Zofran ODT ingredients the tablet may contain. If you experience any serious allergy symptoms, including trouble breathing, swelling of your face and neck, dizziness, swollen lymph nodes, or hives, seek medical attention immediately. When this happens, stop using the medication as soon as possible and seek emergency medical help.

This medication may be contraindicated for people with a history of recent abdominal surgery, gastrointestinal problems, irregular heartbeat, and liver disease. Due to the possibility of drug interactions, you should mention all of your prescription and non-prescription medications, supplements, and herbal products.

There is a possibility that this oral drug can cause QT prolongation, which would be considered a medical emergency. Symptoms are severe dizziness and fainting. Keep hydrated and avoid water pills to prevent this. The blood potassium and magnesium levels should also be monitored, as they can also cause QT prolongation.

Dizziness, lightheadedness, and drowsiness are among the common adverse effects of this medication. Keeping an alert and clear vision is essential when performing tasks requiring alertness. You must also limit your consumption of alcoholic drinks.

This antiemetic prescription drug contains aspartame. The use of this chemical must be restricted for people with phenylketonuria or PKU. Make sure you discuss your condition with your doctor or how you can safely take this medication.

As much as possible, pregnant moms should avoid taking this oral drug because there is evidence proving that it can cause harm to unborn babies. For breastfeeding moms, it is not entirely known if it can pass into breast milk. It is highly important to discuss with the doctor all the possible risks before deciding to take this drug.