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Zofran ODT
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Prescription Prescription Required
Formulation : Orally disintegrating Tablet
Drug Name Dosage Quantity Price Buy Now
Zofran ODT 4mg 10 $101.00 Add To Cart
Zofran ODT
Dosage: 4mg
Quantity: 10
Price: $101.00

See Alternative Pricing below for savings

Buy Ondansetron

(Affordable Generic Alternatives for Zofran ODT)

Prescription Prescription Required
Formulation : Orally Disintegrating Tablet
Drug Name Dosage Quantity Price Buy Now
Ondansetron ODT 4mg 10 $56.00 Add To Cart
Ondansetron ODT 4mg 30 $134.00 Add To Cart
Ondansetron ODT 8mg 10 $70.00 Add To Cart
Ondansetron ODT 8mg 30 $176.00 Add To Cart
Ondansetron ODT
Dosage: 4mg
Quantity: 10
Price: $56.00
Ondansetron ODT
Dosage: 4mg
Quantity: 30
Price: $134.00
Ondansetron ODT
Dosage: 8mg
Quantity: 10
Price: $70.00
Ondansetron ODT
Dosage: 8mg
Quantity: 30
Price: $176.00

Generic Name: ondansetron ODT

Drug Class: 5-HT3 receptor antagonist

Zofran ODT Indications

Zofran ODT is an oral prescription drug used to prevent nausea and vomiting caused by chemotherapy and radiation therapy. It is also used to manage postoperative nausea and vomiting (PONV).

Additional information

Brand Name:

Zofran ODT

Generic name:

Ondansetron, Ondansetron ODT

Other Names:

Ondansetron ODT, Zofran Zydis


4mg, 8mg

Quantities Available:

10, 30


Orally Disintegrating Tablet, Orally disintegrating Tablet

Warning & Dosage

Zofran ODT Dosage Forms

This is available in Zofran ODT 4 mg and 8 mg orally disintegrating tablets.

Zofran ODT Mechanism of Action

The exact mechanism of this prescription drug is not fully known yet. However, this 5-HT3 receptor antagonist is known to be present peripherally on vagal nerve terminals and in the chemoreceptor trigger zone (CTZ) in the area postrema. It also blocks the release of serotonin, subsequently blocking the vomiting reflex.

How to Take Zofran ODT

Before you start with Zofran ODT treatment, it is necessary to read the information leaflet or medication guide given by a healthcare professional. It is important to understand the uses and directions of drugs before using them. Ask your doctor or pharmacist for additional details or further medical advice.

Zofran ODT is meant to be taken sublingually and is usually initiated 30 minutes to 2 hours before treatment and three times a day for one to two days after the procedure. You may administer it with or without a meal. However, most patients are advised not to eat before surgery, radiation therapy, or chemotherapy. The tablet should be placed on the tongue and allowed to dissolve. The medication may take a few seconds or minutes to absorb completely. You may have to limit the drinking of water while on this treatment. Do not chew or swallow this oral drug.

Make a dosing schedule. Do not increase or decrease your Zofran ODT dosage as it is based on your age, weight, overall health condition, and how you will respond to the product. You should also not take it more frequently. Keep taking the medication until the physician prescribes it.

Zofran ODT Warnings and Precautions

Do not take this prescription drug if you have a known allergy to ondansetron, granisetron, other anti-nausea serotonin blockers, or any Zofran ODT ingredients the tablet may contain. If you experience any serious allergy symptoms, including trouble breathing, swelling of your face and neck, dizziness, swollen lymph nodes, or hives, seek medical attention immediately. When this happens, stop using the medication as soon as possible and seek emergency medical help.

This medication may be contraindicated for people with a history of recent abdominal surgery, gastrointestinal problems, irregular heartbeat, and liver disease. Due to the possibility of drug interactions, you should mention all of your prescription and non-prescription medications, supplements, and herbal products.

There is a possibility that this oral drug can cause QT prolongation, which would be considered a medical emergency. Symptoms are severe dizziness and fainting. Keep hydrated and avoid water pills to prevent this. The blood potassium and magnesium levels should also be monitored, as they can also cause QT prolongation.

Dizziness, lightheadedness, and drowsiness are among the common adverse effects of this medication. Keeping an alert and clear vision is essential when performing tasks requiring alertness. You must also limit your consumption of alcoholic drinks.

This antiemetic prescription drug contains aspartame. The use of this chemical must be restricted for people with phenylketonuria or PKU. Make sure you discuss your condition with your doctor or how you can safely take this medication.

As much as possible, pregnant moms should avoid taking this oral drug because there is evidence proving that it can cause harm to unborn babies. For breastfeeding moms, it is not entirely known if it can pass into breast milk. It is highly important to discuss with the doctor all the possible risks before deciding to take this drug.

Side Effects

Zofran ODT Side Effects

Mild & Common Side Effects:

  • Lightheadedness
  • Dizziness
  • Headache
  • Drowsiness
  • Tiredness
  • Weakness
  • Fatigue
  • Constipation

Severe Side Effects:

  • Muscle spasm
  • Muscle stiffness
  • Stomach pain
  • Vision changes
  • Chest pain
  • Irregular heartbeat
  • Severe dizziness
  • Fainting
  • Serotonin syndrome (hallucinations, fast heartbeat, twitching muscles, loss of coordination, restlessness, agitation, unexplained fever)

Note that this is not a full/complete list of the side effects of Zofran ODT.

Your doctor should be contacted if you experience severe or persistent adverse reactions to your medication.


Frequently Asked Questions (FAQs)

What is Zofran ODT used for?

Zofran ODT (ondansetron ODT) is being used to prevent nausea and vomiting. This is usually prescribed by an oncologist for patients undergoing chemotherapy and radiation therapy. It also prevents nausea and vomiting following surgical procedures. It can also lower the risk of aspiration pneumonia.

What does ODT mean in Zofran ODT?

ODT stands for orally disintegrating tablets. This type of oral medication is meant to be administered sublingually and should not be swallowed. Zofran is also available in other forms like oral tablets and oral solutions.

How long does it take Zofran ODT to work?

This antiemetic medication starts working within an hour to two hours after it has been administered. You may have to take it regularly for a few days to maintain its effects.

Can you drink water after taking Zofran ODT?

To use this product, you must place the film on the top of your tongue and wait for it to dissolve for about 20 seconds. You must not swallow it. You may drink water once the product has already dissolved.

Is Zofran ODT sold over the counter?

This oral product is a prescription drug. You need to have a valid prescription before purchasing from any pharmacy. You need to obtain a prescription from your physician. Do not use this medication unless prescribed.

Can I buy Zofran ODT online?

You may buy Zofran ODT in physical drugstores and online pharmacies. You may place your prescription drug orders here in DoctorSolve.

How much does Zofran ODT cost in Canada?

You may check the price of Zofran ODT in Canada at the top of this page. You may purchase this oral drug from this website or order your prescriptions by phone.

Get the best deals when you order your prescription drugs from DoctorSolve. We provide the lowest prices of medication for our patients.

The information above for Zofran ODT (Ondansetron) was provided to by third parties. In no way should this information substitute for the advice of a physician. Consult a doctor or qualified health care professional if you have any medical concerns.