Relafen (Nabumetone)

Do’s

• Start by reading the Medication Guide provided by your pharmacist before using Relafen and consult it each time you get a refill. If you have any questions, ask your healthcare provider for clarification
• Take this medication by mouth as directed by your healthcare provider, usually once or twice daily with a full glass of water (8 ounces or 240 milliliters). 
• To prevent stomach upset, take Relafen with food, milk, or an antacid
• The dosage of Relafen is based on your medical condition and response to treatment. Follow the prescribed dosage to minimize side effect risks such as stomach bleeding. Use the medication at the lowest effective dose for the shortest possible length of time
• For chronic conditions such as arthritis, continue taking Relafen as directed by your healthcare provider and discuss the risks and benefits with them.
• In certain conditions such as arthritis, it may take up to 2 weeks of regular intake before the full benefits of the drug are noticed.
• If you are taking this medication on an "as needed" basis (not on a regular schedule), remember that pain medications work best if they are used as the first signs of pain occur. Waiting until the pain has worsened may result in the medication not working as effectively.
• Tell your healthcare provider if your condition worsens while taking Relafen

Don’t

• Do not lie down for at least 10 minutes after taking the medication.
• Do not increase your dose or take this medication more often than prescribed.

Common Side Effects:

• Stomach pain, indigestion, nausea
• Diarrhea, constipation, gas
• Swelling in hands and feet
• Headache, dizziness
• Itching, skin rash
• Ringing in the ears

Severe Side Effects:

• Liver problems: Symptoms include nausea, upper stomach pain, itching, tired feeling, flu-like symptoms, loss of appetite, dark urine, clay-colored stools, and jaundice (yellowing of the skin or eyes).
• Kidney problems: Symptoms may include little or no urination, painful or difficult urination, swelling in the feet or ankles, feeling tired or short of breath.
• Low red blood cells (anemia): Symptoms may include pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet.
• Cardiovascular thrombotic events
• Gastrointestinal effects

This is not a complete list of side effects, and others may occur. Consult a healthcare provider for medical advice about side effects. 

Relafen may rarely cause serious (rarely fatal) bleeding from the stomach or intestines. This effect can occur without warning symptoms at any time while taking this drug. Older adults may be at higher risk for this effect. Be mindful of any signs of bleeding and seek medical attention if necessary.

Inform your healthcare provider about any history of liver or kidney problems, as Relafen can affect these organs. Monitoring of liver and kidney function may be necessary during treatment.

Relafen can increase the risk of cardiovascular and heart diseases such as strokes and myocardial infarctions, which can lead to death. Individuals with a history of heart disease should inform their healthcare provider before using Relafen

Relafen can cause digestive tract problems such as ulcers, bleeding, inflammation, and perforations. Inform your healthcare provider if you have a history of digestive problems, or if you smoke or frequently drink alcohol.

Inform your healthcare provider about all the medications, supplements, and herbal products you are currently taking, as they may interact with Relafen and cause adverse effects.

This is not an exhaustive list of warnings and precautions for Relafen. Consult a healthcare provider for personalized medical advice and to discuss any specific concerns or medical history that may impact the use of Relafen.