Leucovorin (Calcium Folinate)


(Brand Option)

Prescription RequiredPrescription Required
FormulationFormulation: Tablet
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$210.00 ($8.75 per tablet)

$411.00 ($8.56 per tablet)

Calcium Folinate

(Generic Alternative)

Prescription RequiredPrescription Required

This generic medication is not available at the moment.

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Leucovorin is used to treat or prevent serious blood cell disorders caused by specific medications. These blood cell disorders include:

  • Thrombocytopenia: Low blood platelet count, which can lead to easy bruising or bleeding.
  • Neutropenia: Low neutrophil count, a type of white blood cell important for fighting infections.
  • Anemia: Low red blood cell count, causing fatigue and weakness.

Leucovorin is specifically used to address these disorders when caused by certain drugs known as folic acid antagonists. Examples include methotrexate, trimethoprim, and pyrimethamine.


  • Take the medication exactly as directed by your healthcare provider, including dosage, frequency, and whether to take it with or without food. 
  • Take it regularly at the same time(s) each day for maximum benefit. 
  • Inform your healthcare provider if nausea or vomiting prevents you from taking the medication orally, as they may switch you to the injection form. 

Leucovorin’s dosage depends on your specific medical condition and how well you respond to treatment. 

Common side effects may include:

  • Diarrhea
  • Nausea
  • Itching
  • Difficulty breathing or swallowing

Serious side effects:

  • Severe allergic reactions such as rash, itching, swelling of the face, tongue, or throat, severe dizziness, hives, or trouble breathing
  • Symptoms of methotrexate toxicity, such as mouth sores, diarrhea, vomiting, pale skin, easy bruising or bleeding, weakness, or fever
  • Symptoms of anemia caused by a lack of vitamin B12, such as fatigue, weakness, shortness of breath, pale skin, or rapid heartbeat

This is not an exhaustive list, and other side effects may occur. If you experience any unusual or severe side effects while taking Leucovorin,  contact your healthcare provider for medical advice.

Tell your healthcare provider about any allergies you have, including allergies to leucovorin, levoleucovorin, folic acid, or folinic acid.

Inform your healthcare provider of your medical history, especially if you have a certain type of anemia caused by vitamin B12 deficiency.

Disclose all medications you take (prescription, non-prescription, and herbal) to your healthcare provider or dentist before having surgery.

Leucovorin should only be used during pregnancy if clearly necessary. Discuss the risks and benefits with your healthcare provider.

The safety of Leucovorin during breastfeeding is unknown. Consult your healthcare provider before breastfeeding.

Brand Name:


Generic name:

Calcium Folinate

Other Names:


Strength(s): 5mg
Quantities Available: 24, 48


Important Information
The information above for Leucovorin (Calcium Folinate) was provided to DoctorSolve.com by third parties. In no way should this information substitute for the advice of a physician. Consult a doctor or qualified health care professional if you have any medical concerns.
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