Gelsyn-3 (Sodium Hyaluronate)


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FormulationFormulation: Prefilled Syringe
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Sodium Hyaluronate

(Generic Alternative)

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This generic medication is not available at the moment.

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Gelsyn-3 is a medication used to treat knee pain caused by osteoarthritis. The medication is indicated for patients who have not responded adequately to conservative non-pharmacologic therapy and simple analgesics. 

It is specifically indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics, such as acetaminophen.

Gelsyn-3 contains sodium hyaluronate, a substance used to treat pain in the knee due to osteoarthritis. It works by providing lubrication and cushioning benefits to the knee joint, thereby reducing pain and stiffness associated with osteoarthritis. 


  • Always follow your healthcare provider's instructions
  • exactly regarding dosage, frequency, and duration of use.
  • Take Gelsyn-3 with or without food, as directed by your healthcare provider.
  • Swallow the medication whole with a glass of water. Don't crush, chew, or break the tablets.
  • Tell your healthcare provider about ALL medications you are taking, including prescription drugs, over-the-counter medications, herbal remedies, and supplements. This helps avoid potential interactions.
  • Inform your healthcare provider about any medical conditions you have, especially heart problems, high blood pressure, liver or kidney disease, or stomach ulcers.
  • Be aware of potential side effects and report any that become bothersome or persistent to your healthcare provider.


  • Do not exceed the recommended dosage or take Gelsyn-3 more often than prescribed.
  • Do not stop taking Gelsyn-3 abruptly without consulting your healthcare provider.
  • Do not share Gelsyn-3 with others.
  • Do not operate heavy machinery or drive if Gelsyn-3 causes dizziness or drowsiness.

Common Side Effects:

  • Mild pain or swelling around the knee after the injection
  • Skin irritation at the injection site
  • Mild gastrointestinal upset
  • Itching or rash at the injection site
  • Vaginal discomfort/itching/discharge

Serious Side Effects:

  • Signs of infection in the knee or skin around the knee after the injection
  • Severe pain or swelling around the knee after the injection
  • Allergic reactions such as rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing
  • Neurological symptoms such as numbness/tingling of the hands/feet or seizures
  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheadedness, or passing out

This is not an exhaustive list, and other side effects may occur. If you experience any unusual or severe side effects while taking Gelsyn 3,  contact your healthcare provider for medical advice.

Do not use Gelsyn-3 if you are allergic to sodium hyaluronate. 

Do not inject Gelsyn-3 into your knee if you have an infection in your knee joint or skin around the injection site.

Do not use disinfectants containing quaternary ammonium salts before injecting Gelsyn-3. These disinfectants can cause Gelsyn-3 to clump together.

Do not use Gelsyn-3 if you have a severe buildup of fluid in your knee joint.

Your healthcare provider should remove any fluid buildup in your knee joint before injecting Gelsyn-3.

Use Gelsyn-3 with caution if you have problems with lymphatic drainage or blood flow in your leg.

The safety of using Gelsyn-3 more than once has not been proven.


Brand Name:


Generic name:

Sodium Hyaluronate

Other Names:


Strength(s): 16.8mg/2mL
Quantities Available: 1, 2, 3

Prefilled Syringe

Important Information
The information above for Gelsyn-3 (Sodium Hyaluronate) was provided to by third parties. In no way should this information substitute for the advice of a physician. Consult a doctor or qualified health care professional if you have any medical concerns. widget logo
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