Cymbalta (Duloxetine)

Cymbalta

(Brand Option)

Prescription RequiredPrescription Required
FormulationFormulation: Delayed Release Capsule, DR Capsule
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$550.00 ($9.17 per capsule)

$58.00 ($2.07 per capsule)

$106.00 ($1.89 per capsule)

$154.00 ($1.83 per capsule)

$69.00 ($2.46 per capsule)

$141.00 ($1.68 per capsule)

$166.00 ($1.98 per capsule)

Duloxetine

(Generic Alternative)

Prescription RequiredPrescription Required
FormulationFormulation: Delayed Release Capsule (Enteric Coated), Delayed Release Capsule
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$74.00 ($0.74 per capsule)

$31.00 ($1.11 per capsule)

$63.00 ($0.75 per capsule)

$79.00 ($0.79 per capsule)

$38.00 ($1.36 per capsule)

$69.00 ($1.38 per capsule)

$94.00 ($1.12 per capsule)

$128.00 ($1.28 per capsule)

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Cymbalta (duloxetine) is indicated for the following conditions:

  • Major Depressive Disorder (MDD):
    • Cymbalta is used to treat a certain type of depression called Major Depressive Disorder (MDD).
  • Generalized Anxiety Disorder (GAD)
    • It is also used to treat Generalized Anxiety Disorder (GAD).
  • Diabetic Peripheral Neuropathic Pain (DPNP):
    • Cymbalta is indicated for the treatment of Diabetic Peripheral Neuropathic Pain (DPNP).
  • Fibromyalgia (FM):
    • It is used to manage Fibromyalgia (FM).
    • Clinical studies have shown Cymbalta to be effective at treating fibromyalgia.
    • Patients with fibromyalgia could achieve a 30 percent improvement in pain after taking Cymbalta.
  • Chronic Musculoskeletal Pain:
    • Cymbalta is indicated for the management of Chronic Musculoskeletal Pain.
  • Other Uses:
    • In addition, Cymbalta is used to help chronic muscle or joint pain, osteoarthritis, and nerve pain caused by diabetic neuropathy.

Cymbalta belongs to a class of medicines known as serotonin-norepinephrine reuptake inhibitors (SNRIs).

Do's

  • Take Cymbalta by mouth as directed by your healthcare provider, usually 1 or 2 times a day with or without food.
  • Swallow the capsule whole and do not crush, chew, break, or open it. Doing so can affect how well your body absorbs the drug, potentially increasing the risk for side effects or reducing its effectiveness.
  • Take the medication regularly at the same time(s) each day to get the most benefit from it.
  • Follow all directions on your prescription label and read all medication guides or instruction sheets. Your healthcare provider may occasionally change your dose.
  • Take Cymbalta even if you feel well.
  • If you miss a dose, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and take the next dose as scheduled.
  • If you experience nausea, taking the drug with food may help.

Don'ts

  • Do not crush, chew, break, or open Cymbalta capsules.
  • Do not suddenly stop the medication without consulting your healthcare provider. Suddenly stopping the medication can lead to worsening conditions and withdrawal symptoms such as dizziness, confusion, mood swings, and other discomforts.
  • Do not take two doses at once to make up for a missed dose.

The dosage of Cymbalta is typically based on your age, medical condition, and response to treatment. Your healthcare provider may direct you to start the medication at a low dose and gradually increase it to reduce the risk of side effects.

The recommended dosage for treating fibromyalgia or long-term pain in adults is 60 mg once per day. However, the initial dose may be 30 mg once per day, with a potential increase to 60 mg based on your healthcare provider's assessment.                 

Common Side Effects:

  • Nausea
  • Dry mouth
  • Sleepiness
  • Constipation
  • Loss of appetite
  • Increased sweating
  • Drowsiness
  • Diarrhea
  • Insomnia (trouble sleeping)
  • Headache
  • Tiredness
  • Decreased appetite
  • Hyperhidrosis (excessive sweating)
  • Fatigue
  • Sexual side effects

Not being able to sleep (insomnia) is one of the most common side effects reported by people taking Cymbalta. In some individuals, this side effect may improve after a couple of weeks of taking the medication.

Serious Side Effects:

  • Agitation
  • Hallucinations
  • Fever
  • Sweating
  • Shivering
  • Fast heart rate
  • Muscle stiffness
  • Twitching
  • Loss of coordination
  • Symptoms of serotonin syndrome
  • Liver damage
  • Orthostatic hypotension, which may lead to falls

Consult with a healthcare provider for personalized advice and guidance regarding the potential side effects of Cymbalta.

Cymbalta may interact with other drugs. Consult a healthcare provider before taking any drug, changing any diet, or commencing or discontinuing any course of treatment.

Avoid taking Cymbalta within 5 days before or 14 days after using a MAO inhibitor, as a dangerous drug interaction could occur.

If you are considering breastfeeding while taking Cymbalta, discuss the risks and benefits with your healthcare provider and explore other treatment and feeding options.

Clinical studies have shown that antidepressants such as Cymbalta increase the risk of suicidal thoughts and behaviors in children and young adults ages 24 years or younger.

Excessive alcohol use can damage the liver over time. Therefore, drinking heavily during Cymbalta treatment could raise the risk for liver damage even more.

Cymbalta may cause symptoms of serotonin syndrome; monitor for these symptoms when using the medication.

Adverse reactions after discontinuation of Cymbalta, after abrupt or tapered discontinuation, may include symptoms such as dizziness, headache, nausea, and anxiety. A gradual reduction in dosage rather than abrupt cessation is recommended whenever possible.

The information provided is not exhaustive. Consult with a healthcare provider for personalized advice and guidance regarding the use of Cymbalta.

Generic name:

Duloxetine, Duloxetine Hydrochloride, Duloxetine hydrochloride
Formulation:

Delayed Release Capsule (Enteric Coated), Delayed Release Capsule, DR Capsule
Strength(s): 20mg, 30mg, 40mg, 60mg
Quantities Available: 28, 50, 56, 60, 84, 100
PDFCymbalta product monograph
Important Information
The information above for Cymbalta (Duloxetine) was provided to DoctorSolve.com by third parties. In no way should this information substitute for the advice of a physician. Consult a doctor or qualified health care professional if you have any medical concerns.
Dr. Zickler

Co-founder of DoctorSolve

Dr. Paul Zickler (Retired)

Dr. Paul Zickler co-founded DoctorSolve™ Health Care Solutions in 1999. He graduated from the faculty of medicine at the University of Western Ontario in 1972 and became an Emergency Physician. He practiced as an Emergency Physician for 18 years after which he co-owned and operated several ambulatory medical and travel clinics for 12 years and discovered his interest in prescription medicines.

More about Dr. Paul Zickler
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