Polytrim (Polymixin/trimethoprim)


(Brand Option)

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This brand medication is not available at the moment.


(Generic Alternative)

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This generic medication is not available at the moment.

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Polytrim is used to treat bacterial infections of the eye, such as blepharitis and conjunctivitis. Its targeted use in addressing bacterial eye infections highlights its role in providing effective treatment for these specific conditions.

Polytrim contains two antibiotics, Polymyxin B and Trimethoprim. Polymyxin B works by killing the bacteria, while Trimethoprim works by stopping the growth of the bacteria. This combination of antibiotics provides a comprehensive approach to addressing bacterial eye infections.


  • Wash hands thoroughly before using.
  • Use as directed by your healthcare provider, typically every 3 hours.
  • Follow the application technique: tilt head back, form a pouch with lower eyelid, aim and drop medication, close eye with gentle pressure on inner corner.
  • Use regularly at consistent times.
  • Continue using for the full prescribed duration even if symptoms improve.
  • Inform your healthcare provider about other eye medications you use.
  • Use eye drops before eye ointments.
  • Allow vision to clear before driving or operating machinery.
  • Tell your healthcare provider if your condition worsens or persists.


  • Don't touch the dropper tip to your eye or any surface.
  • Don't wear contact lenses while using Polytrim.
  • Don't swallow or inject Polytrim (for eye use only).
  • Don't rinse the dropper.
  • Don't skip doses or stop using without consulting your healthcare provider.

Common side effects:

  • Ocular side effects are the most common, including local irritation, increased redness, burning, stinging, and/or itching. This may occur on installation, within 48 hours, or at any time with extended use.
  • Temporary burning or stinging, itching, or increased redness when the eye drops are applied.

Serious side effects that may require immediate medical attention include:

  • Eye pain, swelling, redness, or severe discomfort
  • Crusting or drainage (may be signs of infection)
  • Swelling or redness of the eyelids
  • New or worsening symptoms
  • Symptoms of an allergic reaction, such as rash, itching/swelling (especially of the eyes/face/tongue/throat), severe dizziness, trouble breathing

This is not an exhaustive list, and other side effects may occur. If you experience any unusual or severe side effects while taking Polytrim,  contact your healthcare provider for medical advice.

Let your healthcare provider know if you have any allergies to polymyxin B/trimethoprim (the active ingredients in Polytrim) or its other ingredients.

Inform your healthcare provider about any pre-existing health conditions, although the specifics aren't mentioned in the provided excerpt.

Inform your healthcare provider about all medications you take (including Polytrim) before any surgery.

Discuss the risks and benefits of Polytrim with your healthcare provider if you're pregnant or plan to become pregnant. The information mentions the medication is used in the eye, but Polytrim is typically not an eye medication. Clarify with your healthcare provider if Polytrim is indeed for the eye and the associated breastfeeding risks

Medications can interact with each other, affecting how they work or increasing the risk of side effects. This insert doesn't list all possible interactions. Maintain a list of all medications you use, including prescription drugs, over-the-counter drugs, and herbal products. Share this list with your healthcare provider. Never adjust your medication dosage without consulting your healthcare provider.

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Strength(s): noDose
Quantities Available: 10

Eye drops

Important Information
The information above for Polytrim (Polymixin/trimethoprim) was provided to DoctorSolve.com by third parties. In no way should this information substitute for the advice of a physician. Consult a doctor or qualified health care professional if you have any medical concerns.
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