Deplin (L-Methylfolate)


(Brand Option)

Prescription RequiredPrescription Required
FormulationFormulation: Capsule
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$650.00 ($7.22 per capsule)

$650.00 ($7.22 per capsule)


(Generic Alternative)

Prescription RequiredPrescription Required
FormulationFormulation: Tablet
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$149.00 ($1.66 per tablet)

$377.00 ($4.19 per tablet)

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Deplin is indicated for use in individuals who have conditions related to folate deficiency. Specifically, it is used in people with major depressive disorder who have folate deficiency, or in people with schizophrenia who have hyperhomocysteinemia related to folate deficiency

While Deplin is not an antidepressant or antipsychotic medication itself, it may enhance the effects of antidepressant medications when used in combination. It contains L-methylfolate, which is an active form of folate that helps the brain naturally improve mood. Low levels of active folate can make it harder to see results from antidepressant treatment, and not having enough active folate may also put individuals at risk of their depression returning, even after it has gone away


  • Follow your healthcare provider's instructions and the directions on the product package.   
  • Take Deplin by mouth with or without food, as directed by your healthcare provider, usually once daily. 
  • Take Deplin regularly at the same time each day to get the most benefit from it. 
  • Follow the diet plan recommended by your healthcare provider. 
  • Seek medical help right away if your condition lasts or gets worse or if you suspect a serious medical problem. 


  • Do not increase your dose or take Deplin more often than directed. 

The dosage and administration of Deplin (L-methylfolate) may vary depending on your medical condition and the guidance of your healthcare provider. 

Common side effects:

  • Agitation
  • Anxiety
  • Gastrointestinal issues (such as constipation, diarrhea, or nausea)

Serious side effects:

  • Signs of an allergic reaction, such as rash, hives, itching, swelling of the face, lips, tongue, or throat, trouble breathing

This is not an exhaustive list, and other side effects may occur. If you experience any unusual or severe side effects while taking Deplin,  contact your healthcare provider for medical advice.

Here are some warnings and precautions to consider when taking Deplin:

  1. Allergies: Do not use Deplin if you are allergic to L-methylfolate or any of its components.
  2. Interaction with Medications: Deplin may interact with certain medications, such as antidepressants and antiepileptic drugs. It's crucial to inform your healthcare provider about all medications, supplements, or herbal products you are taking.
  3. Medical Conditions: Individuals with certain medical conditions, such as epilepsy or bipolar disorder, should use Deplin with caution and under the guidance of a healthcare provider.
  4. Pregnancy and Breastfeeding: Pregnant or breastfeeding individuals should consult their healthcare provider before using Deplin, as the safety of the supplement during these periods is not well-established.
  5. Methylfolate Accumulation: Deplin is a concentrated form of folate, and excessive levels of methylfolate in the body may have unintended effects. This is particularly important for individuals with certain genetic conditions, such as MTHFR mutations. Therefore, a healthcare provider's guidance is crucial.

Brand Name:


Generic name:

L-Methylfolate, L-Methylfolate

Other Names:

Tetrafol, Deplin, L-Methylfolate

Strength(s): 7.5mg, 15mg
Quantities Available: 90

Tablet, Capsule

Important Information
The information above for Deplin (L-Methylfolate) was provided to by third parties. In no way should this information substitute for the advice of a physician. Consult a doctor or qualified health care professional if you have any medical concerns. widget logo
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