Arthrotec (Diclofenac/Misoprostal)

Do’s

• Reduce stomach upset by taking Arthrotec with a full glass of water and food.
• Swallow whole. Don't crush, chew, or break the tablets. This can increase side effects.
• Avoid lying down for at least 10 minutes after taking Arthrotec.
• Take it consistently: For best results, take Arthrotec at the same time(s) each day.
• Follow the low-dose approach. Discuss the lowest effective dose with your healthcare provider to minimize side effects.
• Aim for the shortest possible treatment duration to reduce risks.
• Disclose all medications (prescription, over-the-counter, vitamins, herbs) to avoid interactions.
• Report any changes in your condition (improvement or worsening) to your healthcare provider.
• Avoid magnesium-containing antacids as they can worsen diarrhea with Arthrotec. Consult your healthcare provider for alternatives.

Don'ts

• Don't skip or alter doses: Stopping Arthrotec abruptly or changing the dosage without your healthcare provider's guidance can be harmful.
• Don't take more than prescribed: Exceeding the prescribed dosage won't necessarily improve results and might cause side effects.
• Don't use it for extended periods: Long-term use of Arthrotec increases the risk of stomach bleeding. Discuss alternative treatment plans with your healthcare provider for chronic conditions.

Common side effects of Arthrotec may include:

• Abnormal vaginal bleeding
• Heartburn
• Indigestion
• Stomach pain
• Gas
• Diarrhea
• Constipation

Serious side effects of Arthrotec are rare but may include:

• Shortness of breath, even with mild exertion
• Swelling or rapid weight gain
• Signs of stomach bleeding, such as bloody or tarry stools, coughing up blood, or vomit that looks like coffee grounds
• Liver problems, including loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes)
• Kidney problems, such as little or no urination, swelling in the feet or ankles, feeling tired or short of breath
• Low red blood cells (anemia), characterized by pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet

This is not an exhaustive list, and other side effects may occur. If you experience any unusual or severe side effects while taking Arthrotec,  contact your healthcare provider for medical advice.

Inform your healthcare provider if you have allergies to Arthrotec, diclofenac, misoprostol, aspirin, other NSAIDs, or any other medications.

Tell your healthcare provider about any pre-existing conditions, especially liver disease, stomach/intestinal/esophageal problems, heart disease, high blood pressure, stroke, swelling, blood disorders, bleeding/clotting problems, aspirin-sensitive asthma, or nasal polyps.

Arthrotec use can cause kidney problems, especially for dehydrated individuals, those with heart failure/kidney disease, older adults, or on certain medications. Drink plenty of fluids as directed by your healthcare provider and inform them of any changes in urine output.

Arthrotec may cause dizziness or drowsiness. Avoid driving, operating machinery, or activities requiring alertness until you feel normal. Limit alcohol and marijuana use which can worsen dizziness.

Arthrotec (diclofenac) may cause stomach bleeding. The risk is increased with daily alcohol and tobacco use. Limit alcohol and stop smoking. Consult your healthcare provider about safe alcohol consumption.

Arthrotec may increase sun sensitivity. Limit sun exposure, avoid tanning booths/lamps, use sunscreen, and wear protective clothing outdoors. Inform your healthcare provider if you get sunburned or have skin blisters/redness.

Inform your healthcare provider about all medications you take (including Arthrotec) before undergoing surgery.

Older adults are more at risk for stomach/intestinal bleeding, kidney problems, heart attack, and stroke while using Arthrotec.

Arthrotec must not be used during pregnancy as it can harm the mother and unborn baby. Use reliable birth control to prevent pregnancy while taking it and for at least one month after stopping treatment. Discuss risks and benefits with your healthcare provider if you are pregnant or plan to become pregnant.

Arthrotec passes into breast milk but is unlikely to harm a nursing infant. Consult your healthcare provider before breastfeeding.