Xerese (Acyclovir/Hydrocortisone)


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FormulationFormulation: Cream
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Xerese Cream contains two active ingredients: acyclovir and hydrocortisone. Acyclovir is an antiviral medication that works by stopping the growth of the virus, while hydrocortisone is a corticosteroid that helps relieve itching, pain, and burning symptoms.

This cream is specifically used to treat cold sores/fever blisters caused by the herpes simplex virus. Its dual-action formulation addresses both the viral growth and the associated symptoms, providing a comprehensive approach to managing the manifestations of the infection.

Xerese Cream has the potential to speed up the healing of cold sores, offering relief from the discomfort and aiding in the resolution of the symptoms associated with the infection.


  • Apply Xerese Cream at the first sign of a cold sore (tingling, burning, itching, redness).
  • Wash your hands thoroughly with soap and water before and after applying the cream.
  • Clean and dry the affected area, then apply a thin layer of cream as directed by your healthcare provider, usually 5 times daily for 5 days. Cover the entire cold sore but avoid rubbing.
  • Avoid touching the cold sore and then your eyes. Wash your hands if you touch the cold sore.
  • Apply a thin layer of the cream to the affected area only. Avoid getting it in your eyes, nose, or mouth. If contact occurs, rinse thoroughly with water.
  • Avoid close contact, such as kissing, while you have a cold sore.


  • Don't use Xerese Cream more often or for longer than prescribed.
  • Don't apply to sensitive areas. Don't get the cream in your eyes, nose, mouth, or genitals.
  • Don't use other skin products like makeup, sunscreen, or lip balm on the treated area during application.
  • Don't cathe/shower too soon. Wait at least 30 minutes after applying the cream before bathing, showering, or swimming.
  • Don't spread the infection. Avoid sharing personal items like utensils, cups, razors, or towels.
  • Don't cover the treated area with bandages or other dressings unless your healthcare provider instructs you to.
  • Don't expect Xerese Cream to cure herpes or prevent transmission of the virus. It can shorten healing time but won't prevent future outbreaks.

Common Side Effects:

  • Mild burning or tingling after applying the medicine
  • Skin dryness or flaking
  • Swelling
  • Skin redness or discoloration

Serious Side Effects:

  • Severe burning, stinging, or irritation of treated skin
  • Allergic reaction: Symptoms may include hives, difficulty breathing, and swelling of the face, lips, tongue, or throat. A very serious allergic reaction to Xerese is rare.
  • Serious eye symptoms: Such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights.

This is not an exhaustive list, and other side effects may occur. If you experience any unusual or severe side effects while taking Xerese,  contact your healthcare provider for medical advice.

Inform your healthcare provider if you are allergic to safinamide or any ingredients in Xadago.

Disclose any pre-existing medical conditions to your healthcare provider before using Xadago, especially:

  • Liver disease
  • High blood pressure
  • Mental/mood disorders (schizophrenia, bipolar disorder, depression)
  • Eye problems (macular degeneration, uveitis)
  • Sleep disorders

Xadago may cause drowsiness or dizziness. Avoid driving, operating machinery, or activities requiring alertness until you are sure you can do them safely. Limit alcohol and marijuana use while taking Xadago.

Tell your healthcare provider about all medications you take, including Xadago, before having surgery.

Xadago should only be used during pregnancy when clearly necessary. Discuss the risks and benefits with your healthcare provider.

It is unknown if Xadago passes into breast milk. Consult your healthcare provider before breastfeeding.

Generic name:




Strength(s): 5/1%
Quantities Available: 5, 10, 15
Important Information
The information above for Xerese (Acyclovir/Hydrocortisone) was provided to DoctorSolve.com by third parties. In no way should this information substitute for the advice of a physician. Consult a doctor or qualified health care professional if you have any medical concerns.
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