Renvela (Sevelamer Carbonate)

Please read the instructions before using Renvela (Sevelamer Carbonate).

Do’s

• Take Renvela by mouth as directed by your healthcare provider, usually 3 times daily with meals. Swallow the tablet whole.
• The dosage is based on your medical condition, any other medications you take to lower your phosphate levels, and your response to treatment. In children, the dosage is also based on body size.
• If you are taking the powder form of Renvela, check the manufacturer package directions for mixing it with water, beverage, or food and taking it within 30 minutes. 
• Follow the directions for the proper amount of water to use for your dose. Stir the mixture well and drink all of it. If the powder settles to the bottom of the cup, stir again right before drinking. You may also mix the powder with a small amount of food or beverage to take as part of a meal.
• Take this medication regularly in order to get the most benefit from it. Remember to take it 3 times a day with meals, or on the schedule given to you by your healthcare provider.

Don’ts

• Do not crush, chew, or split the tablet.
• If mixing the powder form of Renvela with food or beverage, do not heat the powder or add it to heated foods or liquids.

Common Side Effects

• Nausea, vomiting, stomach pain, loss of appetite
• Upset stomach, gas, bloating
• Diarrhea, constipation
• Tired feeling
• Itching
• Joint pain

Severe Side Effects:

• Seek emergency medical help if you experience signs of an allergic reaction to Renvela, such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat.
• Stop using Renvela and call your healthcare provider at once if you experience choking or trouble swallowing, black, bloody, or tarry stools, severe constipation with stomach pain, or constipation that gets worse or does not clear up.

Renvela may cause gastrointestinal effects, including severe problems in the digestive tract such as blockages and holes. Inform your healthcare provider if you have a history of swallowing disorders, digestive tract surgery, or severe constipation.

Consult healthcare providers for personalized advice and report any side effects experienced. Always seek medical advice if you have concerns about the use of Renvela.

Store Renvela at room temperature away from light and moisture. Do not store it in the bathroom. Keep all medications away from children and pets. Properly discard this product when it is expired or no longer needed.

Do not use Renvela if you have a history of bowel obstruction or if you are allergic to sevelamer carbonate or sevelamer hydrochloride or to any of the ingredients in Renvela. Report new onset or worsening of existing constipation or bloody stools promptly to a healthcare provider.

Avoid taking any other medicines within 1 hour before or 3 hours after taking Renvela, as sevelamer can bind to other medications and make them less effective.

Consult healthcare providers for personalized advice and to ensure the safe use of Renvela. Always seek medical advice if you have concerns about the use of this medication.

Renvela Drug Interactions

Ciprofloxacin: Renvela can lower ciprofloxacin absorption, making it less effective. Take ciprofloxacin at least 2 hours before or 6 hours after Renvela. Levothyroxine: It may reduce levothyroxine absorption, leading to inadequate thyroid hormone levels. Take levothyroxine at least 4 hours before Renvela. Mycophenolate Mofetil: Renvela can decrease the bioavailability of mycophenolate mofetil, which may weaken its immunosuppressive effects. Oral Medications: Renvela can interfere with the absorption of many oral drugs. Take other medications at least 1 hour before or 3 hours after Renvela. Fat-Soluble Vitamins: It may reduce absorption of vitamins A, D, E, and K. Patients may need vitamin supplements. Cinacalcet: Renvela does not significantly affect cinacalcet’s pharmacokinetics. Studies show no major interaction when taken together. Always inform your doctor about all medications, supplements, and herbal products you take to prevent harmful interactions.

How do I store Renvela?

Store at 25°C (77°F): excursions permitted to 15°C-30°C (59°F-86°F).

Generic name:	Sevelamer Carbonate, Sevelamer Carbonate
Formulation:	Tablet
Strength(s):	800mg
Quantities Available:	100, 180, 200, 360