Steglujan (Ertugliflozin/Sitagliptin)

Do’s

• Take Steglujan by mouth, with or without food, as prescribed by your healthcare provider.
• Take it once daily, usually in the morning.
• Take it consistently at the same time each day to maximize its effectiveness.
• Inform your healthcare provider if your blood sugar levels improve or worsen (too high or too low).

Don'ts

• Don't alter the dosage or frequency unless instructed by your healthcare provider.
• Don't skip or stop taking Steglujan without consulting your healthcare provider.
• Don't take Steglujan with other medications (including supplements) without informing your healthcare provider about potential interactions.

Common side effects:

• Fungal infections of the vagina and other infections of the female reproductive system
• Stomach upset
• Signs of a urinary tract infection (such as burning/painful/frequent/urgent urination, pink/bloody urine)
• Signs of kidney problems (such as change in the amount of urine, swelling legs/feet)
• Joint pain
• Unusual skin blisters
• Signs of heart failure (such as shortness of breath, swelling ankles/feet, unusual tiredness, unusual/sudden weight gain)

Serious side effects that may require immediate medical attention include:

• Symptoms of pancreatitis: severe pain in the upper stomach spreading to the back, with or without nausea and vomiting
• Serious infections in the penis or vagina, with symptoms such as burning, itching, odor, discharge, pain, tenderness, redness, or swelling of the genital or rectal area, fever, or feeling unwell
• Signs of an allergic reaction (hives, difficult breathing, swelling in the face or throat) or a severe skin reaction (fever, sore throat, burning in the eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling)
• Bullous pemphigoid, a skin condition that causes large, fluid-filled blisters
• Severe joint pain
• Hypersensitivity reactions, including anaphylaxis, angioedema, and exfoliative skin conditions such as Stevens-Johnson syndrome

This is not an exhaustive list, and other side effects may occur. If you experience any unusual or severe side effects while taking Steglujan,  contact your healthcare provider for medical advice.

Be sure to tell your healthcare provider about any allergies you have before taking Steglujan. This includes allergies to ertugliflozin, sitagliptin, or any other ingredients.

Inform your healthcare provider about your medical history, especially if you have any of the following conditions:

• Kidney disease or failure (dialysis)
• Heart failure
• Dehydration
• Low blood pressure
• Pancreatitis
• Alcohol use or abuse
• Gallstones
• Yeast infections
• Blocked arteries in the legs
• Nerve problems in the feet (diabetic peripheral neuropathy)
• Foot sores or ulcers
• Amputation

Steglujan may cause dizziness, blurred vision, or drowsiness. Avoid driving, operating machinery, or any activities requiring alertness until you know how this medication affects you.

Limit alcohol consumption while taking Steglujan as it can increase your risk of low blood sugar and high ketone levels.

Stress and illness can make it harder to control your blood sugar. Consult your healthcare provider if you experience fever, infection, injury, surgery, or any other illness, as your treatment plan may need to be adjusted.

Inform your healthcare provider about all medications you take (prescription, non-prescription, and herbal) before having surgery.

Older adults may be more at risk for certain side effects, including dizziness, dehydration, and kidney problems.

Steglujan should only be used during pregnancy if clearly necessary. Discuss the risks and benefits with your healthcare provider.

Pregnancy can worsen diabetes. Talk to your healthcare provider about managing your blood sugar during pregnancy. Your treatment plan may be adjusted.

It is unknown if Steglujan passes into breast milk. Consult with your healthcare provider before breastfeeding.