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Janumet XR
(Sitagliptin/Metformin HCI XR)

Prescription Prescription Required
Formulation : Extended Release Tablet
Drug Name Dosage Quantity Price Buy Now
Janumet XR 50/1000mg 56 $180.00 Add To Cart
Janumet XR 50/500mg 60 $175.00 Add To Cart
Janumet XR 50/1000mg 112 $355.00 Add To Cart
Janumet XR 50/500mg 120 $335.00 Add To Cart
Janumet XR 50/1000mg 168 $530.00 Add To Cart
Janumet XR 50/500mg 180 $495.00 Add To Cart
Janumet XR 100/1000mg 28 $101.00 Add To Cart
Janumet XR 100/1000mg 84 $293.00 Add To Cart
Janumet XR
Dosage: 50/1000mg
Quantity: 56
Price: $180.00
Janumet XR
Dosage: 50/500mg
Quantity: 60
Price: $175.00
Janumet XR
Dosage: 50/1000mg
Quantity: 112
Price: $355.00
Janumet XR
Dosage: 50/500mg
Quantity: 120
Price: $335.00
Janumet XR
Dosage: 50/1000mg
Quantity: 168
Price: $530.00
Janumet XR
Dosage: 50/500mg
Quantity: 180
Price: $495.00
Janumet XR
Dosage: 100/1000mg
Quantity: 28
Price: $101.00
Janumet XR
Dosage: 100/1000mg
Quantity: 84
Price: $293.00

Janumet XR Description 

This diabetes drug Janumet XR 50 1000 mg has been approved for the treatment of type 2 diabetes. 

The once-daily tablet combines metformin hydrochloride, a biguanide used to treat type 2 diabetes, and sitagliptin phosphate monohydrate, an inhibitor of the dipeptidyl peptidase-4 (DPP-4) enzyme. 

This drug is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both metformin and sitagliptin is appropriate.

Additional information

Brand Name:

Janumet XR

Generic name:

Sitagliptin/Metformin HCI XR

Other Names:

Janumet XR


50/500mg, 50/1000mg, 100/1000mg

Quantities Available:

28, 56, 60, 84, 112, 120, 168, 180


Extended Release Tablet

Warning & Dosage


  • It is important to take Janumet XR exactly as prescribed by your doctor.
  • Do not take more medication than prescribed, and do not stop taking the medication until you have had an opportunity to talk to your doctor.
  • Do not crush or chew the tablets; they must be swallowed whole.
  • If you miss a dose, take it as soon as you remember, but do not take more than one dose per day.
  • If an overdose of this medicine occurs, you must contact poison control immediately.


  • As with all medications, there are certain things you need to be aware of before taking Janumet XR. These cautions include the following:
  • Do not take Janumet XR if you are allergic to metformin or any of the other ingredients in the medication.
  • Do not take this drug if you have liver problems or kidney problems.
  • If you are nursing or pregnant, do not take medication.
  • Be sure to drink plenty of fluids while taking it, as it can cause dehydration.
  • Be aware that this medication can cause lactic acidosis, a condition that can be serious and even fatal

Side Effects

Janumet XR Side Effects 

  • Janumet XR diarrhea: It may cause diarrhea, which can be a sign of a serious condition. If you have diarrhea that does not go away, or if it gets worse, call your doctor right away.
  • It may cause some side effects, including nausea, vomiting, diarrhea, headache, and stomach pain. In some cases, it may also cause low blood sugar levels.


Frequently Asked Questions 

Can Janumet XR be taken twice daily? 

Janumet XR should be taken once daily. It is important to take it as prescribed by your doctor in order to control your blood sugar levels. If you have any questions or concerns about taking this medicine, be sure to speak with your doctor.

How does Janumet XR work? 

Janumet XR works by decreasing the amount of sugar that is produced by the liver and by helping the body use insulin more effectively. It is important to follow your doctor’s instructions carefully when taking this drug, as it can cause side effects such as nausea, vomiting, and diarrhea.

What makes Janumet and Janumet XR so different? 

The difference between Janumet and Janumet XR, they are both prescription medications used to control blood sugar in adults with type 2 diabetes. They help by working in conjunction with exercise and eating healthily. Janumet is twice-daily, while Janumet XR (extended-release) is taken once daily.

What are the alternatives to Janumet XR? 

Depending on your condition, these are possible alternatives but always talk to your doctor before making any changes. 

  • Metformin – Metformin is a medicine that helps the body use insulin better. It is usually the first medicine prescribed for people with type 2 diabetes. 
  • Sulfonylureas – Sulfonylureas are a class of medicines that help the pancreas make more insulin. 
  • Pioglitazone and Rosiglitazone – Pioglitazone and rosiglitazone are medicines that help the body use insulin better. They are called thiazolidinediones, or TZDs. 
  • Insulin – Some people with type 2 diabetes need to take insulin because their bodies do not make enough on their own. 

Pricing: How much does Janumet XR cost in Canada?  

Janumet XR price will depend on the quantity and dosage. Check the top of this page for pricing.  

The information above for Janumet XR (Sitagliptin/Metformin HCI XR) was provided to by third parties. In no way should this information substitute for the advice of a physician. Consult a doctor or qualified health care professional if you have any medical concerns.