Stiolto Respimat (Tiotropium Bromide/Olodaterol)

Stiolto Respimat is taken as two inhalations once daily, and that single daily dose is also the maximum recommended dose.

Standard adult dosage

• Typical dose for adults with COPD: 2 puffs by mouth once per day, at about the same time each day. Each puff delivers 2.5 mcg tiotropium and 2.5 mcg olodaterol, for a total of 5 mcg/5 mcg per day.
• Do not take more than 2 puffs (one dose) in any 24‑hour period; higher or more frequent dosing is not recommended.

Form and strength

• Stiolto Respimat comes as a soft‑mist inhaler containing a single fixed strength: 2.5 mcg tiotropium plus 2.5 mcg olodaterol per actuation (per puff).
• All usual dosing schedules for COPD use this same strength; the regimen is adjusted by timing and adherence, not by changing the number of puffs beyond 2 per day.

Use and missed doses

• If a dose is missed, it can be taken when remembered, but no more than one dose (2 puffs) should be used within 24 hours; the next dose should then be taken at the regular time the following day.
• Stiolto Respimat is a maintenance inhaler, not a rescue inhaler, so a separate fast‑acting bronchodilator (such as albuterol) is typically used for sudden breathing symptoms.

Common side effects of Stiolto Respimat occur in more than 3% of users and include cough, nasopharyngitis (common cold symptoms), and back pain.

Other frequent mild effects

• Runny or stuffy nose, sore throat, or sinus inflammation.
• ​Dry mouth, dizziness, difficulty sleeping (insomnia), or constipation.

Managing side effects

Most mild effects like cough or cold symptoms resolve within days to weeks and rarely lead to stopping treatment. Persistent or bothersome effects warrant a discussion with your doctor, who may adjust therapy or check for interactions.

What is albuterol called in Canada?

In Canada, albuterol is known as salbutamol, a short-acting beta-agonist used for quick relief. Unlike Stiolto Respimat, which is a long-acting maintenance inhaler, salbutamol targets acute symptoms.

What is the difference between Spiriva Respimat and Stiolto Respimat?

Spiriva Respimat delivers tiotropium alone. Stiolto Respimat combines tiotropium with olodaterol (a LABA), offering dual bronchodilation and superior lung function improvement.

Does Spiriva improve lung function?

Yes, tiotropium improves sustained bronchodilation, exercise tolerance, and reduces exacerbations. Stiolto Respimat further improves FEV1 by combining tiotropium with olodaterol.

How long does a Stiolto Respimat inhaler last?

Each device contains 60 puffs; at two puffs once daily, it lasts 30 days. The cartridge expires 3 months after insertion, but will be empty in 30 days of correct use.

Can I buy albuterol over the counter in Canada?

No, salbutamol inhalers are Schedule 1 drugs requiring a prescription, just like Stiolto Respimat.