About Pertzye (Lipase/Protease/Amylase)
- Pertzye is a prescription medication used to treat people who have difficulty digesting food because their pancreas does not produce enough enzymes owing to cystic fibrosis or other diseases.
- Cystic fibrosis (CF) is a genetic disease that runs in families. It is caused by a faulty gene that causes the body to create abnormally thick and sticky mucus. This mucus accumulates in the lungs’ and pancreas’ breathing channels.
- Pertzye pills contain a blend of digestive enzymes derived from the pig pancreas, including lipases, proteases, and amylases.
- Lipases, proteases, and amylases are all enzymes that play a role in the digestion of food. Lipases break down fats, proteases break down proteins, and amylases break down carbohydrates.
- Pertzye is a medication that contains all three of these enzymes. It is used to treat digestive disorders such as pancreatitis and some other diseases.
- Pertzye is taken by mouth with or without food. It is available in capsules or as a powder that can be mixed with water or other liquids.
- Pertzye is safe and effective in children when used as directed by your doctor.
Uses of Pertzye (Lipase/Protease/Amylase)
- The drug works by breaking down fats, proteins, and carbohydrates into their simplest form, allowing for easier absorption by the body.
- Pertzye is most commonly used to treat Crohn’s disease, ulcerative colitis, and pancreatitis. The medication can also be used to treat indigestion, heartburn, and diarrhea.
- Pertzye is taken orally or through a gastrostomy tube. The lowest indicated dose should be started and gradually increased. The dosage of Pertzye should be tailored to the patient’s clinical symptoms, degree of steatorrhea, and dietary fat content.
Patients may be dosed using either a fat ingestion-based or an actual body weight-based strategy.
- Infants (up to 12 months)
Infants can get 4,000 lipase units (one capsule) for every 120 ml of formula or breast milk. Pertyze capsule contents should not be mixed directly into formula or breast milk.
- Children between the ages of 12 months and 4 years
For children under the age of four, enzyme dosing should begin with 1,000 lipase units/kg of body weight per meal and progress to a maximum of 2,500 lipase units/kg of body weight per meal (or less than or equal to 10,000 lipase units/kg of body weight per day), or less than 4,000 lipase units/g fat ingested per day.
- Adults and children aged 4 and up
Enzyme dosing for those over the age of 4 years should begin with 500 lipase units/kg of body weight per meal and progress to a maximum of 2,500 lipase units/kg of body weight per meal (or less than or equal to 10,000 lipase units/kg of body weight per day), or less than 4,000 lipase units/g fat ingested per day.
Half of the specified Pertzye dose for an individualized complete meal should be administered with each snack. The entire daily dose should consist of three meals and two or three snacks daily.
Because older patients weigh more but consume less fat per kilogram of body weight, enzyme doses expressed as lipase units/kg of body weight per meal should be reduced.
Delayed Release Capsule
Warnings and Dosage
Interactions and Warnings Of Pertzye (Lipase/Protease/Amylase)
Tell your doctor about all of your medical conditions before using Pertzye, including if you:
- are sensitive to pork (pig) goods
- have a history of bowel obstruction, scarring, or thickening of the gut wall (fibrosing colonopathy)
- have gout, renal problems, or elevated blood uric acid levels (hyperuricemia)
- pills are difficult to swallow
- have any additional medical issues
- are pregnant or intend to get pregnant It is unknown whether Pertzye will harm your unborn child.
- are breastfeeding or intend to start breastfeeding It is unknown whether Pertzye enters your breast milk. You and your doctor must decide whether to take Pertzye or breastfeed.
Inform your doctor about all your medications, including prescription and over-the-counter medications, vitamins, and dietary or herbal supplements.
Pertzye (pancrelipase) has 25 known medication interactions, 1 disease interaction, and 1 alcohol/food interaction. Twenty-five of the total medication interactions is moderate.
Medications that have been shown to interact with pancrelipase:
- aluminum hydroxide
- calcium carbonate
- carbonyl iron
- ferric maltol
- ferrous fumarate
- ferrous gluconate
- ferrous sulfate
- folic acid
- glycerol phenylbutyrate
- heme iron polypeptide
- iron polysaccharide
- iron protein succinylate
- levomefolate calcium
- magnesium hydroxide
- multivitamin with iron
- multivitamin with iron and fluoride
- multivitamin with minerals
- multivitamin, prenatal
- sodium bicarbonate
Interactions Between Pertzye and Alcohol/Food:
- Pancrelipase may impair folic acid and iron efficacy by interfering with absorption.
- It is critical to inform your doctor about any additional medications you are taking, including vitamins and herbs. Do not discontinue any medications without first consulting your doctor.
Disease interactions with Pertzye (pancrelipase) include:
Side Effects of Pertzye (Lipase/Protease/Amylase)
Some pancrelipase adverse effects may occur, however, they normally do not necessitate medical treatment. These adverse effects may subside as your body responds to the medication. Your doctor can also advise you on how to avoid or mitigate some of these adverse effects.
Consult your doctor if any of the following side effects persist or become bothersome or if you have any questions about them.
- vision impairment
- arid mouth
- skin flushed and dry
- fruity breath odor
- increased appetite
- thirst heightened
- heightened urination
- unaccounted for weight loss
Pancrelipase (the active ingredient in Pertzye) may have certain undesired side effects besides its necessary functions. Consult your doctor right away if you experience any of the following negative effects while using pancrelipase:
- Hives or skin rash.
In large doses:
- bowel obstruction
- stomach discomfort or cramps
With extremely high doses:
- urine with blood
- joint discomfort
- edema in the feet or legs.
Frequently Asked Questions about Pertzye (Lipase/Protease/Amylase)
How should Pertzye be stored?
Pertzye should be kept in its original container and stored at room temperature, between 68°F and 77°F (20°C and 25°C). To keep your medicine dry, close the bottle tightly after opening it (protect it from moisture).
The Pertzye bottle has a desiccant packet to help keep your medicine dry (protect it from moisture). Keep Pertzye and any medicines out of the reach of children.
How does Pertzye affect breastfeeding?
Pancrelipase has been utilized in breastfed infants whose mothers had an evident allergy to proteins in breast milk acquired from the maternal diet. This approach has reduced symptoms of egg allergy and cow’s milk allergy, including blood in the stool and colic. Pancreatic enzymes are not absorbed much from the mother’s gastrointestinal tract and should not reach the newborn. Experts believe that using pancrelipase while breastfeeding is safe.
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Pertzye (Lipase/Protease/Amylase) Price
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The information above for Pertzye (Lipase/Protease/Amylase) was provided to DoctorSolve.com by third parties. In no way should this information substitute for the advice of a physician. Consult a doctor or qualified health care professional if you have any medical concerns.