Amitiza (Lubiprostone)


(Brand Option)

Prescription RequiredPrescription Required
FormulationFormulation: Capsule
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$526.00 ($8.77 per capsule)

$421.00 ($7.02 per capsule)


(Generic Alternative)

Prescription RequiredPrescription Required
FormulationFormulation: Soft Gelatin Capsule
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$70.00 ($1.17 per capsule)

$178.25 ($0.99 per capsule)

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Amitiza, with the generic name lubiprostone, is indicated for the following conditions:

  • Chronic Idiopathic Constipation (CIC) in Adults: Amitiza is used to treat chronic constipation in adults.
  • Opioid-Induced Constipation (OIC) in Adult Patients With Chronic Non-Cancer Pain: It is indicated for the treatment of constipation caused by opioid (narcotic) pain medicine in adult patients with chronic non-cancer pain, including those with chronic pain related to prior cancer or its treatment who do not require frequent opioid dosage escalation.
  • Irritable Bowel Syndrome with Constipation (IBS-C) in Women: Amitiza is indicated for the treatment of irritable bowel syndrome with constipation in women at least 18 years old.

Amitiza increases the secretion of fluid in the intestines to help make it easier to pass stools (bowel movements).


  • Take this medication by mouth with food and water as directed by your healthcare provider, usually twice daily. 
  • Swallow the medication whole. 
  • Follow the specific dosage instructions provided by your healthcare provider. 
  • Use this medication regularly to derive the maximum benefit from it. 
  • Remember to take it at the same time each day to maintain a consistent level of medication in your system. 
  • Have regular discussions with your healthcare provider about whether you still need this treatment. They can assess your condition and determine the ongoing need for this medication.   
  • Inform your healthcare provider if your condition persists or worsens so they can evaluate your treatment and make any necessary adjustments. 


  • Do not break or chew the medication. 

The dosage of Amitiza is determined based on your medical condition and response to treatment. 

Common Side Effects:

  • Headache
  • Stomach pain
  • Diarrhea
  • Gas and bloating
  • Nausea
  • Dizziness
  • Trouble breathing (generally goes away after a few hours)

Most of these side effects may go away within a few days or a couple of weeks. If they are more severe or do not go away, talk to your healthcare provider.

Serious Side Effects:

  • Dizziness
  • Full or bloated feeling or pressure in the stomach
  • Swelling of the abdominal or stomach area
  • Black, tarry stools
  • Blood in the stools
  • Chest discomfort or pain
  • Chills
  • Cold symptoms
  • Cough
  • Difficult or labored breathing
  • Fever

This is not an exhaustive list of side effects, and other side effects may occur. If you experience any concerning symptoms while taking Amitiza, seek medical advice promptly.

Before taking Amitiza, consult with a healthcare provider to ensure that the medication is safe, appropriate, and effective for the individual. Moreover, consult a healthcare provider before making any changes to the medication, diet, or commencing or discontinuing any course of treatment.

Amitiza should not be used if there is a blockage in the digestive tract or in cases of severe diarrhea. It is also contraindicated in patients with known or suspected mechanical gastrointestinal obstruction.

Nursing mothers should be cautious as a nursing baby could develop diarrhea if the mother takes Amitiza while breastfeeding. Inform the healthcare provider if breastfeeding a baby and discuss any potential development of diarrhea in the baby.

There are concerns regarding the use of Amitiza during pregnancy. Consult your healthcare provider before taking Amitiza if you are pregnant.

Always consult a healthcare provider for personalized advice and guidance regarding the use of Amitiza.

Generic name:

Lubiprostone, Lubiprostone


Capsule, Soft Gelatin Capsule

Strength(s): 8mcg, 24mcg
Quantities Available: 60, 180
Important Information
The information above for Amitiza (Lubiprostone) was provided to by third parties. In no way should this information substitute for the advice of a physician. Consult a doctor or qualified health care professional if you have any medical concerns. widget logo
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