Jentadueto (Linagliptin/Metformin)

Do’s

• Before taking Jentadueto, read the Medication Guide and, if available, the Patient Information Leaflet provided by your pharmacist. If you have any questions, ask your healthcare provider for clarification.
• Take this medication by mouth as directed by your healthcare provider, usually twice daily with meals.
• Drink plenty of fluids while taking this medication unless otherwise directed by your healthcare provider.
• The dosage of Jentadueto is based on your medical condition, response to treatment, and other medications you may be taking. Make sure to inform your healthcare provider about all the products you use, including prescription drugs, nonprescription drugs, and herbal products.
• To reduce the risk of side effects (such as upset stomach), your healthcare provider may advise you to start this medication at a low dose and gradually increase your dose. Follow their instructions carefully.
• Take this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day
• Carefully follow the medication treatment plan, meal plan, and exercise program recommended by your healthcare provider.
• If your condition does not improve or worsens (for example, if your blood sugar is too high or too low), inform your healthcare provider. 

Common Side Effects:

• Diarrhea
• Upset stomach
• Nausea
• Vomiting
• Headache
• Nasopharyngitis (inflammation of the nose and throat)

Serious Side Effects:

• Pancreatitis
• Skin reactions
• Joint pain
• Increased blood sugar
• Symptoms of lactic acidosis, such as muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, dizziness, or slow or uneven heart rate

Seek medical attention if you experience any serious side effects.

This is not an exhaustive list of side effects, and individual experiences may vary. If you have any specific concerns about the side effects of Jentadueto, discuss them with your healthcare provider.

Consult a healthcare provider before taking any medication, including Jentadueto to ensure that the use of the drug is safe, appropriate, and effective for your specific health condition and circumstances.

Steps to reduce the risk of and manage metformin-associated lactic acidosis are provided in the full prescribing information. If metformin-associated lactic acidosis is suspected, immediate discontinuation of Jentadueto and institution of general supportive measures in a hospital setting is recommended.

Discontinue Jentadueto if the patient's estimated glomerular filtration rate (eGFR) falls below a certain level and at the time of, or prior to, certain medical procedures. Re-evaluate eGFR after the imaging procedure and restart Jentadueto if renal function is stable.

Patients should be informed that acute pancreatitis has been reported during the use of linagliptin. Persistent severe abdominal pain, sometimes radiating to the back, is the hallmark symptom of acute pancreatitis. Patients should discontinue Jentadueto promptly and contact their healthcare provider if persistent severe abdominal pain occurs.

The risk of hypoglycemia is increased when Jentadueto is used in combination with certain medications such as insulin secretagogues or insulin. Patients should be informed about this risk.

Risk factors for metformin-associated lactic acidosis include renal impairment, concomitant use of certain drugs, age 65 years old or greater, and having a radiological study with contrast. Patients should be informed about hypersensitivity reactions and associated risk factors.

This is not an exhaustive list of warnings and precautions. Always consult your healthcare provider for personalized advice and guidance regarding the use of Jentadueto.