Nexlizet (Bempedoic acid/Ezetimibe)

Do not take Nexlizet if you are allergic to ezetimibe tablets. Ezetimibe, one of the active ingredients in Nexlizet, can cause serious allergic reactions such as anaphylaxis, angioedema, rash, and urticaria. Stop taking Nexlizet, call your healthcare provider or go to the nearest hospital emergency room right away if you have any signs or symptoms of an allergic reaction including:

• swelling of your face, lips, mouth or tongue
• Wheezing
• Severe itching
• Fast heart beat or pounding in your chest
• Trouble breathing
• Skin rashes, redness, or swelling
• Dizziness or fainting.

Before you start taking Nexlizet, tell your healthcare provider about all your medical conditions, including if you:

• have or had gout.
• have or had tendon problems.
• are pregnant or think you may be pregnant. Tell your healthcare provider right away if you become pregnant while taking Nexlizet. You and your healthcare provider will decide if you should take Nexlizet while you are pregnant. If you are pregnant during the treatment, you are encouraged to call Esperion at 1-833-377-7633 to share information about the health of you and your baby.
• are breastfeeding or plan to breastfeed. It is not known if Nexlizet passes into your breast milk. You and your healthcare provider should decide if you will take this drug or breastfeed. You should not do both.
• have severe kidney problems.
• have moderate or severe liver problems.

Nexlizet may affect the way other medicines work, and other medicines may affect how this drug works. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take or plan to take:

• simvastatin or pravastatin (other cholesterol lowering medicines). Taking simvastatin or pravastatin with Nexlizet may increase your risk of developing muscle pain or weakness (myopathy).
• cyclosporine (often used in organ transplant patients)
• fibrates (used to lower cholesterol)
• cholestyramine (used to lower cholesterol)

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

Please read the instructions before using Nexlizet tablets.

• Take Nexlizet exactly as your healthcare provider tells you to take it. Check with your healthcare provider or pharmacist if you are not sure.
• Take 1 tablet by mouth each day.
• Swallow the tablet whole. Do not cut, chew, or crush the tablet.
• You may take Nexlizet with or without food.
• If you take a medicine that lowers cholesterol by binding bile acids, such as colesevelam or cholestyramine, take Nexlizet at least 2 hours before or 4 hours after you take bile acid binding medicines. Ask your healthcare provider if you are not sure if you take these medicines. 
• If you take too much Nexlizet, call your poison control center at 1-800-222-1222 or go to the nearest hospital emergency room right away.

How should I store Nexlizet?

• Store Nexlizet in the original package at room temperature between 68ºF to 77ºF (20ºC to 25ºC). 
• Protect from heat and moisture. 
• Do not throw away the packet that helps to keep your medicine dry (desiccant).
• Nexlizet comes in a bottle with a child-resistant cap.

Keep Nexlizet and all medicines out of the reach of children.

What are the ingredients in Nexlizet?

• active ingredients: bempedoic acid and ezetimibe
• inactive ingredients: colloidal silicon dioxide, hydroxy propyl cellulose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, povidone k30, sodium lauryl sulfate, sodium starch glycolate 
• tablet coating: fd&c blue #1/brilliant blue fcf aluminum lake, fd&c blue #2/indigo carmine aluminum lake, glyceryl monocaprylocaprate, partially hydrolyzed polyvinyl alcohol, sodium lauryl sulfate, talc, and titanium dioxide

The most common side effects of Nexlizet include:

• Symptoms of the common cold, flu, or flu-like symptoms
• Back pain
• Bronchitis
• Anemia
• Diarrhea
• Muscle spasms
• Stomach pain
• Pain in shoulder, legs or arms
• Increased liver enzymes
• Fatigue

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Nexlizet. Ask your healthcare provider or pharmacist for more information.