Gemtesa (Vibegron)

To ensure the safe and effective use of Gemtesa, following your doctor's prescription and instructions is essential.

• Take this medication precisely as prescribed, and carefully read and follow all directions on your prescription label, medication guides, or instruction sheets.
• The typical dosage is one 75mg tablet, taken orally once daily.
• As preferred, take the tablet with a full glass of water, with or without food.
• If you have difficulty swallowing tablets, you may crush the tablet and mix it with 1 tablespoon of applesauce.
• Swallow the mixture immediately with a glass of water.
• Do not save the mixture for future use.

Before you take Gemtesa, tell your doctor about all of your medical conditions, including if you have:

• liver problems
• kidney problems
• trouble emptying your bladder or have a weak urine system
• been taking medicines that contain digoxin (Lanoxin tablet, Lanoxin Solution)
• an ongoing pregnancy or plan to become pregnant
• to breastfeed

Side Effects

The most common side effects of Gemtesa include:

• urinary tract infection
• headache
• nasal congestion, sore throat or runny nose
• nausea
• diarrhea
• upper respiratory tract infection

If you have any concerns or questions about potential side effects or reactions to Gemtesa, consult your healthcare provider for further evaluation and guidance.

How should I store this medication?

Store Gemtesa at room temperature between 68°F to 77°F (20°C to 25°C).

How much does Gemtesa cost in Canada?

30 tablets of Gemtesa 75mg dosage costs $514 on Doctor Solve. This excludes the shipping fee. Call +1-866-732-0305 or live chat with our customer support to know more about Gemtesa pricing and refill options.

Can you take this medication twice a day?

Per the approved prescribing information and dosing guidelines, Gemtesa (Vibegron) is typically taken once daily. The recommended dosage for Gemtesa is usually one 75 mg tablet, taken orally once daily with a full glass of water. It is essential to follow the dosing instructions provided by your healthcare provider or as mentioned on the prescription label.

How long does it take for this medication to work?

This medication starts working upon the first dose, although it may take several weeks for symptom relief to be noticeable. Clinical studies have shown that individuals who received Gemtesa treatment experienced decreased overactive bladder symptoms over time.

Is there a generic version of Gemtesa?

Vibegron is a generic option for this medication.

What medications should not be taken along with this medication?

The following medications, including their generic names, have known interactions with Gemtesa:

1. Adagrasib
2. Darifenacin
3. Digoxin
4. Elacestrant
5. Fesoterodine
6. Flavoxate
7. Mirabegron
8. Olutasidenib
9. Oxybutynin
10. Pirtobrutinib
11. Pralsetinib
12. Solifenacin
13. Tolterodine
14. Trospium

How long does Gemtesa stay in your system?

Gemtesa (vibegron) stays in your system for a considerable time after discontinuation due to its long half-life. Here are the key points about how long Gemtesa remains in your system:

1. The effective half-life of vibegron is 30.8 hours [1]
2. The terminal plasma half-life ranges from 60 to 70 hours (approximately 2.5 to 3 days) [2].
3. Gemtesa reaches steady-state concentrations within 7 days of once-daily dosing [3].
4. Following a radiolabeled dose, approximately 59% of the dose (54% as unchanged drug) was recovered in feces, and 20% (19% as unchanged) in urine [2][1].

Why is Gemtesa so expensive?

Gemtesa is expensive because it is a brand-name drug with no generic alternative [4], high research and development costs, limited competition, and patent protection. Manufacturing and distribution expenses also contribute to its high price. As of August 2024, a 30-day supply costs around $486, though retail prices may vary.

Is Gemtesa available in Canada?

Yes, a 30-tablet supply of Gemtesa 75mg is available on DoctorSolve, a Canadian mail-order pharmacy.

Resources

• [1] Patient Information. 2024
• [2] Vibegron
• [3] Clinical Pharmacology Update: Gemtesa From Urovant Sciences. 2021
• [4] Gemtesa Prices, Coupons, Copay Cards & Patient Assistance