Xadago (Safinamide Methansulfonate)


(Brand Option)

Prescription RequiredPrescription Required
FormulationFormulation: Tablet
Select Dosage

Select Quantity

$391.00 ($4.34 per tablet)

$470.00 ($5.22 per tablet)

Safinamide Methansulfonate

(Generic Alternative)

Prescription RequiredPrescription Required

This generic medication is not available at the moment.

Norton Shopping Guarantee

Xadago is used in combination with another medication, levodopa/carbidopa, to treat symptoms of Parkinson's disease. This combination therapy is aimed at improving symptoms such as shakiness, stiffness, and difficulty moving, as well as reducing the amount of "off" time, characterized by periods of slow movement or stiffness.

Safinamide belongs to a class of drugs known as MAO inhibitors, and it works by increasing the levels of certain natural substances in the brain, such as dopamine. This mechanism is crucial in addressing the underlying neurochemical imbalances associated with Parkinson's disease, which is thought to be caused by too little dopamine in the brain.

The medication's ability to address a range of symptoms, including shakiness, stiffness, difficulty moving, and "off" time, highlights its comprehensive approach to managing the multifaceted manifestations of Parkinson's disease.


  • Take Xadago exactly as prescribed by your healthcare provider, typically once daily with or without food.
  • Take it consistently at the same time each day to maximize its effectiveness.
  • Follow your healthcare provider's instructions regarding dosage and duration of treatment. Don't adjust your dose or take it more often than prescribed.
  • Inform your healthcare provider about all medications you take, including prescriptions, over-the-counter drugs, vitamins, and herbal products. This helps avoid potential interactions.
  • Report any side effects you experience to your healthcare provider.
  • Tell your healthcare provider if your condition worsens or if Xadago seems to be less effective.


  • Don't stop taking Xadago abruptly. Your healthcare provider may need to gradually decrease your dose to avoid worsening your condition.
  • Don't consume large amounts of tyramine-rich foods while taking Xadago and for 2 weeks after stopping it. Consult your healthcare provider for a list of foods to avoid.
  • Don't take Xadago if you are allergic to safinamide or any other ingredient in the medication.

Common Side Effects:

  • Dyskinesia: Uncontrolled and sudden body movements.
  • Hypertension: High blood pressure.
  • Increased serum alanine aminotransferase: An enzyme found in the liver, and increased levels may indicate liver damage.
  • Mild burning or tingling after applying the medicine
  • Skin dryness or flaking
  • Swelling
  • Skin redness or discoloration
  • Problems related to sleep

Serious Side Effects:

  • Allergic Reaction: Signs of an allergic reaction may include hives, difficult breathing, and swelling of the face, lips, tongue, or throat.
  • Serotonin Syndrome
  • Confusion
  • Excess sweating
  • Blood pressure changes
  • Muscle spasms or stiffness
  • Diarrhea
  • Very high fever.
  • Withdrawal Effects
  • Very serious high blood pressure reaction

This is not an exhaustive list, and other side effects may occur. If you experience any unusual or severe side effects while taking Xadago,  contact your healthcare provider for medical advice.

Inform your healthcare provider if you are allergic to safinamide or any ingredients in Xadago.

Disclose any pre-existing medical conditions to your healthcare provider before using Xadago, especially:

  • Liver disease
  • High blood pressure
  • Mental/mood disorders (schizophrenia, bipolar disorder, depression)
  • Eye problems (macular degeneration, uveitis)
  • Sleep disorders

Xadago may cause drowsiness or dizziness. Avoid driving, operating machinery, or activities requiring alertness until you are sure you can do them safely. Limit alcohol and marijuana use while taking Xadago.

Tell your healthcare provider about all medications you take, including Xadago, before having surgery.

Xadago should only be used during pregnancy when clearly necessary. Discuss the risks and benefits with your healthcare provider.

It is unknown if Xadago passes into breast milk. Consult your healthcare provider before breastfeeding.


Brand Name:


Generic name:

Safinamide Methansulfonate

Other Names:


Strength(s): 50mg, 100mg
Quantities Available: 90


Important Information
The information above for Xadago (Safinamide Methansulfonate) was provided to DoctorSolve.com by third parties. In no way should this information substitute for the advice of a physician. Consult a doctor or qualified health care professional if you have any medical concerns.
Doctorsolve.com widget logo