Combigan (Brimonidine Tartrate/Timolol Maleate)


(Brand Option)

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FormulationFormulation: Eye Drops
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Brimonidine Tartrate/Timolol Maleate

(Generic Alternative)

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Combigan (brimonidine tartrate/timolol maleate ophthalmic solution) is indicated for the reduction of elevated intraocular pressure (IOP) in patients with glaucoma or ocular hypertension who require adjunctive or replacement therapy due to inadequately controlled IOP. The IOP-lowering effect of Combigan, when dosed twice a day, is slightly less than that seen with the concomitant administration of timolol maleate ophthalmic solution, 0.5% dosed twice a day, and brimonidine tartrate ophthalmic solution, 0.2% dosed three times per day.


  • Follow the prescribed dosage of Combigan, typically one drop in the affected eye(s) twice daily, approximately 12 hours apart. 
  • Wash your hands before applying the eye drops to avoid contamination. 
  • Tilt your head back slightly, pull down your lower eyelid, hold the dropper directly over your eye, and place one drop in the pouch. 
  • Replace the dropper cap after each use. 
  • Remove contact lenses before using Combigan and wait at least 15 minutes after applying the medication before reinserting them. 
  • Wait several minutes for your vision to clear before driving or operating machinery. 
  • Use Combigan regularly at the same times each day to maximize its effectiveness. 
  • Continue using the medication even if you feel well, as most people with glaucoma or high pressure in the eyes do not feel sick. 


  • Do not alter the prescribed dosage of Combigan without consulting your healthcare provider. 
  • Avoid blinking or rubbing your eyes after using Combigan. 
  • Avoid rinsing the dropper after using Combigan to prevent contamination. 

 The dosage and administration of Combigan (brimonidine/timolol) eye drops are essential to ensure the medication's effectiveness and minimize the risk of side effects.  

Common Side Effects:

  • Ocular Side Effects
    • Burning or stinging in the eyes
    • Red eyes
    • Itchy eyes
    • Dry eyes
  • Systemic Side Effects
    • Headache
    • Dizziness
    • Fatigue
    • Changes in taste sensation
  • Cardiovascular Side Effects
    • Decreased heart rate (bradycardia)
    • Decreased blood pressure
  • Respiratory Side Effects
    • Shortness of breath or difficulty breathing

This is not an exhaustive list, and other side effects may occur. If you experience any unusual or severe side effects while taking Combigan,  contact your healthcare provider for medical advice.

Here are some warnings and precautions to consider when taking Combigan:

Reactive Airway Disease: Combigan is contraindicated in patients with reactive airway disease, including bronchial asthma, a history of bronchial asthma, or severe chronic obstructive pulmonary disease (COPD)

Sinus Bradycardia, AV Block, Cardiac Failure: Combigan is contraindicated in patients with sinus bradycardia, second or third-degree atrioventricular block, overt cardiac failure, or cardiogenic shock

Neonates and Infants: Combigan is contraindicated in neonates and infants under the age of 2 years

Hypersensitivity Reactions: Local hypersensitivity reactions have occurred with the use of different components of Combigan. It is contraindicated in patients who have exhibited a hypersensitivity reaction to any component of the medication in the past

Pregnancy: Combigan may be unsafe to use during pregnancy. Animal studies have shown adverse effects on the fetus, although there are limited human studies. The benefits of use in pregnant women may be acceptable despite the risks. Consult with a healthcare provider regarding the use of Combigan during pregnancy.

Interaction with Other Eye Medications: If you are using other eye medications, wait at least 10 minutes before applying them after using Combigan. This helps ensure proper absorption and prevents one medication from washing out the other.

Generic name:

Brimonidine Tartrate/Timolol Maleate, Brimonidine Tartrate/Timolol Maleate


Eye Drops

Strength(s): 0.2/0.5%
Quantities Available: 5, 10, 15
Important Information
The information above for Combigan (Brimonidine Tartrate/Timolol Maleate ) was provided to by third parties. In no way should this information substitute for the advice of a physician. Consult a doctor or qualified health care professional if you have any medical concerns. widget logo
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