Asacol (Mesalamine)


(Brand Option)

Prescription RequiredPrescription Required
FormulationFormulation: DR Tablet, Modified Release Tablet
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$110.00 ($1.31 per tablet)

$91.00 ($0.91 per tablet)

$170.00 ($1.01 per tablet)

$164.25 ($0.82 per tablet)


(Generic Alternative)

Prescription RequiredPrescription Required
FormulationFormulation: Delayed Release Tablet
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$71.50 ($0.48 per tablet)

$87.00 ($0.48 per tablet)

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Asacol is a medication used to treat a specific bowel disease called ulcerative colitis.It is effective in reducing symptoms associated with ulcerative colitis, including diarrhea, rectal bleeding, and stomach pain.

The active ingredient in Asacol is mesalamine, which belongs to a class of drugs known as aminosalicylates. Mesalamine works by decreasing inflammation and swelling in the colon, providing relief from symptoms.


  • Take Asacol as directed by your healthcare provider, usually 3 times daily.
  • Some Asacol brands require an empty stomach (1 hour before or 2 hours after meals). Consult your healthcare provider for specific brand recommendations.
  • Swallow whole. Avoid crushing, chewing, or breaking the tablets to ensure proper release of the medication in your colon.
  • Drink plenty of fluids unless your healthcare provider advises otherwise to prevent kidney stones during Asacol treatment.
  • Take Asacol at the same time(s) each day for optimal benefit.
  • Inform your healthcare provider if your condition doesn't improve or worsens.


  • Don't adjust the dosage or use Asacol for longer than prescribed without consulting your healthcare provider.
  • Don't switch Asacol brands without your healthcare provider's approval, as different brands may have varying strengths.

Common side effects of Asacol may include:

  • Headache
  • Nausea
  • Diarrhea
  • Abdominal pain
  • Flatulence (gas)
  • Indigestion

Serious side effects of Asacol are rare but may include:

  • Allergic reactions: Some individuals may experience hypersensitivity reactions, which can lead to serious problems such as myocarditis or pericarditis.
  • Liver problems: Liver failure is possible with Asacol, especially in individuals with pre-existing liver disease.
  • Worsening of ulcerative colitis symptoms: Rarely, mesalamine can worsen ulcerative colitis. If your symptoms worsen after starting this medication, such as increased abdominal pain, cramping, or bloody diarrhea, it's important to inform your healthcare provider.
  • Kidney problems: Signs of kidney problems, such as changes in urine output or blood in the urine, should be reported to your healthcare provider.

This is not an exhaustive list, and other side effects may occur. If you experience any unusual or severe side effects while taking Asacol,  contact your healthcare provider for medical advice.

Inform your healthcare provider if you have allergies to mesalamine, other aminosalicylates, salicylates (aspirin), sulfasalazine, or any other medications before using Asacol.

Tell your healthcare provider about pre-existing conditions: Discuss any history of kidney disease, liver disease, or stomach blockage (pyloric stenosis) with your healthcare provider before using Asacol.

Protect yourself from the sun: Asacol can increase sun sensitivity. Limit sun exposure, avoid tanning booths/lamps, use sunscreen, and wear protective clothing outdoors. Tell your healthcare provider immediately if you get sunburned or experience skin blisters/redness.

Inform your healthcare provider about all medications: Disclose all medications you take (including Asacol) to your healthcare provider before undergoing surgery.

Avoid Asacol for children/teens with certain conditions: Children and teenagers under 18 with chickenpox, flu, undiagnosed illness, or recent vaccinations should not take Asacol (similar to aspirin) due to the risk of Reye's syndrome.

Use only when necessary: Asacol should only be used during pregnancy if the benefits clearly outweigh the risks. Discuss risks and benefits with your healthcare provider before using it if you are pregnant.

Asacol passes into breast milk and may affect the nursing infant. Consult your healthcare provider to determine if it's safe to use while breastfeeding.

Generic name:

Mesalamine, Mesalamine


DR Tablet, Delayed Release Tablet, Modified Release Tablet

Strength(s): 400mg
Quantities Available: 84, 100, 150, 168, 180, 200
Important Information
The information above for Asacol (Mesalamine) was provided to by third parties. In no way should this information substitute for the advice of a physician. Consult a doctor or qualified health care professional if you have any medical concerns. widget logo
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