DDAVP (Desmopressin)

Do's

• Take DDAVP (desmopressin) by mouth as directed by your healthcare provider for the treatment of diabetes insipidus, usually 2 to 3 times a day. 
• Take DDAVP by mouth as directed by your healthcare provider for the treatment of bedwetting, usually once a day at bedtime. 
• Limit the fluids children drink after dinner, especially 1 hour before the desmopressin dose until the next morning, or at least 8 hours after the dose. If your child wakes up during the night, limit the amount that your child drinks. 
• Consult your healthcare provider for details on fluid intake restrictions for patients taking desmopressin, especially children and older adults. 
• Take this medication regularly to get the most benefit from it, and to help you remember, take it at the same time(s) each day. 

Don'ts

• Do not take more desmopressin or take it more often than prescribed. 

DDAVP is used to control the amount of urine your kidneys make, especially in conditions such as "water diabetes" (diabetes insipidus), or certain kinds of head injury or brain surgery. It helps to control increased thirst and too much urination due to these conditions and helps prevent dehydration. Dosage is based on your medical condition and response to treatment. 

Before taking DDAVP, it is important to be aware of the following warnings and precautions:

1. Allergies: Do not use DDAVP if you are allergic to desmopressin or any of its components.
2. Fluid Retention: DDAVP can cause fluid retention, which may worsen underlying conditions that are susceptible to volume status. Patients with heart failure or uncontrolled hypertension may be at increased risk. DDAVP is not recommended in patients at risk for increased intracranial pressure or those with a history of urinary retention. Limit fluid intake as advised by your healthcare provider.
3. Hyponatremia: DDAVP can cause hyponatremia (low sodium levels in the blood), which can be serious. It is contraindicated in patients with hyponatremia or a history of hyponatremia. Monitor sodium levels closely during treatment.
4. Hypotension and Hypertension: DDAVP can cause changes in blood pressure. Use with caution in patients with coronary artery insufficiency and/or hypertensive cardiovascular disease. Monitor blood pressure regularly.
5. Increased Risk of Thrombosis: DDAVP may increase the risk of thrombosis (formation of blood clots) in patients with von Willebrand's Disease Type IIB. Use with caution in these patients.
6. Hypersensitivity Reactions: DDAVP may cause hypersensitivity reactions. Seek medical attention if you experience signs of an allergic reaction, such as rash, itching, swelling, dizziness, or difficulty breathing.
7. Drug Interactions: Inform your healthcare provider about all the medications you are taking, as there may be potential interactions with DDAVP. Certain drugs, such as tricyclic antidepressants, selective serotonin re-uptake inhibitors, chlorpromazine, opiate analgesics, thiazide diuretics, NSAIDs, lamotrigine, sulfonylureas, chlorpropamide, oxybutynin, and carbamazepine, may increase the risk of hyponatremia when used concomitantly with DDAVP

Side Effects

The side effects of DDAVP (desmopressin) may vary from person to person.

Some common side effects that may occur include:

• Headache
• Dizziness
• Nausea
• Dry mouth
• Mild stomach pain

Serious side effects are rare but can occur.

• Low levels of sodium in the body, which may cause symptoms such as headache, confusion, muscle cramps, severe weakness, vomiting, loss of coordination, restlessness, or unsteadiness
• Flushing (sudden warmth, redness, or tingly feeling)
• Swelling or weight gain
• Seizures
• Weak or shallow breathing
• Light-headedness or feeling like you might pass out

This is not an exhaustive list, and other side effects may occur. If you experience any unusual or severe side effects while taking DDAVP,  contact your healthcare provider for medical advice.

How much does DDAVP cost?

The cost of DDAVP varies based on factors such as dosage and pack size. In the United States, a 90-tablet pack of 0.1 mg DDAVP costs about $184.89 on average at major retail pharmacy chains. If you're looking for a more affordable option, Canadian pharmacies offer significantly lower prices. Through DoctorSolve.com, the same 90-tablet pack is available for approximately $169.50—a savings of around 8% compared to U.S. retail prices. This makes Canadian pharmacies an excellent choice for those seeking cost-effective access to their prescription medications.

Can I buy Desmopressin over the counter?

No, you cannot buy Desmopressin over the counter because it is a prescription drug that requires medical supervision. Since it can cause serious side effects such as dangerously low sodium in the blood (hyponatremia) leading to confusion, seizures, or severe weakness, a doctor must monitor its use to ensure safety.

How much does Desmopressin cost?

The cost of Desmopressin varies based on factors such as dosage and pack size. In the United States, a 100-tablet pack of 0.1 mg Desmopressin costs about $339.92 on average at major retail pharmacy chains. If you're looking for a more affordable option, Canadian pharmacies offer significantly lower prices. Through DoctorSolve.com, the same 100-tablet pack is available for approximately $205—a savings of around 40% compared to U.S. retail prices. This makes Canadian pharmacies an excellent choice for those seeking cost-effective access to their prescription medications.